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Science 17 February 1984:
Vol. 223. no. 4637, pp. 709 - 712
DOI: 10.1126/science.6695179
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Articles

Science, Vol 223, Issue 4637, 709-712
Copyright © 1984 by American Association for the Advancement of Science

articles

Intracellular study of human epileptic cortex: in vitro maintenance of epileptiform activity?

PA Schwartzkroin and WD Knowles

Intracellular recordings were obtained in the vitro slice preparation from neurons of lateral and mesial temporal cortex removed from human epileptics suffering from intractable temporal lobe seizures. Spontaneous rhythmic synaptic events, which were capable of triggering action potential discharge, were observed in many neurons, particularly in mesial tissue slices. Such activity may reflect the epileptogenic capacity of this human cortex.


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