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Science 10 February 1984:
Vol. 223. no. 4636, pp. 605 - 607
DOI: 10.1126/science.6695173
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Articles

Science, Vol 223, Issue 4636, 605-607
Copyright © 1984 by American Association for the Advancement of Science

articles

Epinephrine enables Pavlovian fear conditioning under anesthesia

NM Weinberger, PE Gold, and DB Sternberg

Rats under Pavlovian defensive conditioning (noise paired with shock) while under general anesthesia. Peripheral administration of epinephrine (0.01 to 1.0 milligram per kilogram of body weight) during training resulted in the acquisition of conditioned fear, as shown 10 days later by conditioned suppression of water drinking. Analysis of heart rate and measurement of reflexes during training indicated that epinephrine did not lighten the state of anesthesia. These results indicate that epinephrine enables the learning of conditioned fear in the anesthetized brain.


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