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Science 10 February 1984:
Vol. 223. no. 4636, pp. 594 - 597
DOI: 10.1126/science.6695170
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Articles

Science, Vol 223, Issue 4636, 594-597
Copyright © 1984 by American Association for the Advancement of Science

articles

Adaptive response of human lymphocytes to low concentrations of radioactive thymidine

G Olivieri, J Bodycote, and S Wolff

When human lymphocytes were cultured with [3H]thymidine, which acts as a source of low-level chronic radiation, and then exposed to 150 rad of x-rays at 5, 7, 9, or 11 hours before fixation, the yield of chromatid aberrations was less than the sum of the yields of aberrations induced by [3H]thymidine and x-rays separately. Often fewer aberrations were found after exposure to radiation from both sources than were found after exposure to x-rays alone. At the same fixation times, nonradioactive thymidine did not affect the yield of x-ray-induced aberrations. The same phenomenon occurred at earlier fixation times, after exposure to 30 or 40 rad of x-rays and [3H]thymidine. This response is analogous to the adaptive response to alkylating agents whereby prior treatment with small doses for a long period reduces the damage occurring from large doses of similar agents given for a short time.


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