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Science 10 February 1984:
Vol. 223. no. 4636, pp. 593 - 594
DOI: 10.1126/science.6695169
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Articles

Science, Vol 223, Issue 4636, 593-594
Copyright © 1984 by American Association for the Advancement of Science

articles

Antigenic similarity between cells transformed by ultraviolet radiation in vitro and in vivo

MS Fisher, ML Kripke, and GL Chan

Cells of the 10T 1/2 mouse fibroblast line transformed in vitro by ultraviolet radiation are antigenically similar to those from skin cancers produced in mice by repeated exposure to ultraviolet radiation. Both types of tumor cells grew preferentially in ultraviolet-irradiated syngeneic mice relative to untreated animals, and both were recognized by ultraviolet radiation-induced tumor-specific suppressor lymphocytes. These properties were not shared by 10T 1/2 cells transformed in vitro by x-rays or 3-methylcholanthrene.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)