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Science 3 February 1984:
Vol. 223. no. 4635, pp. 503 - 504
DOI: 10.1126/science.6691162
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Articles

Science, Vol 223, Issue 4635, 503-504
Copyright © 1984 by American Association for the Advancement of Science

articles

Kainic acid induces sprouting of retinal neurons

L Peichl and J Bolz

The neurotoxin kainic acid caused dose-dependent morphological changes in horizontal cells of the retinas of adult cats and rabbits. High concentrations of kainic acid killed the cells, but when exposed to sublethal doses they contracted their dendritic fields and sent sprouting processes into the inner retina. It appears that kainic acid can induce neuronal growth as well as degeneration and that the potential for morphological plasticity is still present in neurons of the adult mammalian retina.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Viscoelastic properties of individual glial cells and neurons in the CNS.
Y.-B. Lu, K. Franze, G. Seifert, C. Steinhauser, F. Kirchhoff, H. Wolburg, J. Guck, P. Janmey, E.-Q. Wei, J. Kas, et al. (2006)
PNAS 103, 17759-17764
   Abstract »    Full Text »    PDF »
Mosaic Regularity of Horizontal Cells in the Mouse Retina Is Independent of Cone Photoreceptor Innervation.
M. A. Raven and B. E. Reese (2003)
Invest. Ophthalmol. Vis. Sci. 44, 965-973
   Abstract »    Full Text »    PDF »


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