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Science 3 February 1984:
Vol. 223. no. 4635, pp. 493 - 496
DOI: 10.1126/science.223.4635.493
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Articles

Guidance of Peripheral Pioneer Neurons in the Grasshopper: Adhesive Hierarchy of Epithelial and Neuronal Surfaces

JOHN BERLOT 1 and COREY S. GOODMAN 1

1 Department of Biological Sciences, Stanford University, Stanford, California 94305

An important question in developmental neurobiology is how a neuron finds its way over long distances to its correct target during embryogenesis. Peripheral pioneer neurons in insect embryos have been used for study because of the relative simplicity of the early embryonic appendages, and the accessibility of the identified neurons whose growth cones traverse this terrain. The data presented suggest an adhesive hierarchy of both epithelial and neuronal surfaces that guides the first growth cones from the appendages of the grasshopper embryo.

Submitted on August 5, 1983
Accepted on November 14, 1983


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