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Science 20 January 1984:
Vol. 223. no. 4633, pp. 301 - 303
DOI: 10.1126/science.6701514
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Articles

Science, Vol 223, Issue 4633, 301-303
Copyright © 1984 by American Association for the Advancement of Science

articles

Activation of pontine cholinergic sites implicated in unconsciousness following cerebral concussion in the cat

RL Hayes, CM Pechura, Y Katayama, JT Povlishock, ML Giebel, and DP Becker

Low levels of cerebral concussion in the cat produce reversible behavioral suppression presumably associated with unconsciousness. This injury is also associated with increased rates of glucose utilization in regions within the dorsomedial pontine tegmentum. Microinjection of carbachol into these regions produced behavioral suppression resembling that following concussion. These data, together with previously published observations on cholinergic responses to brain injury, suggest that concussive unconsciousness may be attributable in part to activation of cholinergic pontine sites.


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Correlation of Regional Metabolic Rates of Glucose with Glasgow Coma Scale After Traumatic Brain Injury.
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