Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 January 1984:
Vol. 223. no. 4633, pp. 296 - 299
DOI: 10.1126/science.6701513
Prev | Table of Contents | Next

Articles

Science, Vol 223, Issue 4633, 296-299
Copyright © 1984 by American Association for the Advancement of Science

articles

Cerebellum: essential involvement in the classically conditioned eyelid response

DA McCormick and RF Thompson

Classical conditioning of the eyelid response in the rabbit was used to investigate the neuronal structures mediating basic associative learning of discrete, adaptive responses. Lesions of the ipsilateral dentate-interpositus nuclei, but not of the cerebellar cortex, abolished the learned eyeblink response. Recordings from these nuclei have revealed neuronal responses related to the learning of the response. Stimulating these recording sites produced the eyelid response. The dentate-interpositus nuclei were concluded to be critically involved in the learning and production of classically conditioned responses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stimulation of the lateral geniculate, superior colliculus, or visual cortex is sufficient for eyeblink conditioning in rats.
H. E. Halverson, E. M. Hubbard, and J. H. Freeman (2009)
Learn. Mem. 16, 300-307
   Abstract »    Full Text »    PDF »
Secretin Effects on Cerebellar-Dependent Motor Learning in Schizophrenia.
A. R. Bolbecker, W. P. Hetrick, J. K. Johannesen, B. F. O'Donnell, J. E. Steinmetz, and A. S. Shekhar (2009)
Am J Psychiatry 166, 460-466
   Abstract »    Full Text »    PDF »
Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning.
B. E. Kalmbach, T. Ohyama, J. C. Kreider, F. Riusech, and M. D. Mauk (2009)
Learn. Mem. 16, 86-95
   Abstract »    Full Text »    PDF »
Mechanisms of Potentiation of Mossy Fiber EPSCs in the Cerebellar Nuclei by Coincident Synaptic Excitation and Inhibition.
J. R. Pugh and I. M. Raman (2008)
J. Neurosci. 28, 10549-10560
   Abstract »    Full Text »    PDF »
Lock-and-Key Mechanisms of Cerebellar Memory Recall Based on Rebound Currents.
D. Z. Wetmore, E. A. Mukamel, and M. J. Schnitzer (2008)
J Neurophysiol 100, 2328-2347
   Abstract »    Full Text »    PDF »
Cerebellar Dysfunction Explains the Extinction-Like Abolition of Conditioned Eyeblinks After NBQX Injections in the Inferior Olive.
S. Zbarska, J. R. Bloedel, and V. Bracha (2008)
J. Neurosci. 28, 10-20
   Abstract »    Full Text »    PDF »
Single-Unit Firing in Rat Perirhinal Cortex Caused by Fear Conditioning to Arbitrary and Ecological Stimuli.
S. C. Furtak, T. A. Allen, and T. H. Brown (2007)
J. Neurosci. 27, 12277-12291
   Abstract »    Full Text »    PDF »
Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission.
N. Wada, Y. Kishimoto, D. Watanabe, M. Kano, T. Hirano, K. Funabiki, and S. Nakanishi (2007)
PNAS 104, 16690-16695
   Abstract »    Full Text »    PDF »
Acquisition, Extinction, and Reacquisition of a Cerebellar Cortical Memory Trace.
D.-A. Jirenhed, F. Bengtsson, and G. Hesslow (2007)
J. Neurosci. 27, 2493-2502
   Abstract »    Full Text »    PDF »
Learning-Induced Plasticity in Deep Cerebellar Nucleus.
T. Ohyama, W. L. Nores, J. F. Medina, F. A. Riusech, and M. D. Mauk (2006)
J. Neurosci. 26, 12656-12663
   Abstract »    Full Text »    PDF »
From the Cover: Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum.
M. T. Dang, F. Yokoi, H. H. Yin, D. M. Lovinger, Y. Wang, and Y. Li (2006)
PNAS 103, 15254-15259
   Abstract »    Full Text »    PDF »
Endogenous Cannabinoid Signaling through the CB1 Receptor Is Essential for Cerebellum-Dependent Discrete Motor Learning..
Y. Kishimoto and M. Kano (2006)
J. Neurosci. 26, 8829-8837
   Abstract »    Full Text »    PDF »
Purkinje cell loss by OX7-saporin impairs acquisition and extinction of eyeblink conditioning..
B. C. Nolan and J. H. Freeman (2006)
Learn. Mem. 13, 359-365
   Abstract »    Full Text »    PDF »
Timing of Conditioned Eyeblink Responses Is Impaired in Cerebellar Patients.
M. Gerwig, K. Hajjar, A. Dimitrova, M. Maschke, F. P. Kolb, M. Frings, A. F. Thilmann, M. Forsting, H. C. Diener, and D. Timmann (2005)
J. Neurosci. 25, 3919-3931
   Abstract »    Full Text »    PDF »
Glutamate Neurotransmission in the Cerebellar Interposed Nuclei: Involvement in Classically Conditioned Eyeblinks and Neuronal Activity.
D. P. Aksenov, N. A. Serdyukova, J. R. Bloedel, and V. Bracha (2005)
J Neurophysiol 93, 44-52
   Abstract »    Full Text »    PDF »
Extinction as New Learning Versus Unlearning: Considerations from a Computer Simulation of the Cerebellum.
M. D. Mauk and T. Ohyama (2004)
Learn. Mem. 11, 566-571
   Abstract »    Full Text »    PDF »
A Central Role for Norepinephrine in the Modulation of Cerebellar Learning Tasks.
M. C. Cartford, T. Gould, and P. C. Bickford (2004)
Behav Cogn Neurosci Rev 3, 131-138
   Abstract »    PDF »
Developmental Changes in the Neural Mechanisms of Eyeblink Conditioning.
J. H. Freeman Jr. and D. A. Nicholson (2004)
Behav Cogn Neurosci Rev 3, 3-13
   Abstract »    PDF »
Neural Circuit of Tail-Elicited Siphon Withdrawal in Aplysia. I. Differential Lateralization of Sensitization and Dishabituation.
A. S. Bristol, M. A. Sutton, and T. J. Carew (2004)
J Neurophysiol 91, 666-677
   Abstract »    Full Text »    PDF »
Neural Substrates of Eyeblink Conditioning: Acquisition and Retention.
K. M. Christian and R. F. Thompson (2003)
Learn. Mem. 10, 427-455
   Abstract »    Full Text »    PDF »
Developmental Changes in Eyeblink Conditioning and Neuronal Activity in the Pontine Nuclei.
J. H. Freeman Jr. and A. S. Muckler (2003)
Learn. Mem. 10, 337-345
   Abstract »    Full Text »    PDF »
Stimulus Generalization of Conditioned Eyelid Responses Produced Without Cerebellar Cortex: Implications for Plasticity in the Cerebellar Nuclei.
T. Ohyama, W. L. Nores, and M. D. Mauk (2003)
Learn. Mem. 10, 346-354
   Abstract »    Full Text »    PDF »
Classical Conditioning and Modification of the Rabbit's (Oryctolagus Cuniculus) Unconditioned Nictitating Membrane Response.
B. G. Schreurs (2003)
Behav Cogn Neurosci Rev 2, 83-96
   Abstract »    PDF »
Comparison of eyeblink conditioning in patients with superior and posterior inferior cerebellar lesions.
M. Gerwig, A. Dimitrova, F. P. Kolb, M. Maschke, B. Brol, A. Kunnel, D. Boring, A. F. Thilmann, M. Forsting, H. C. Diener, et al. (2003)
Brain 126, 71-94
   Abstract »    Full Text »    PDF »
A Biophysical Model of Nonlinear Dynamics Underlying Plateau Potentials and Calcium Spikes in Purkinje Cell Dendrites.
S. Genet and B. Delord (2002)
J Neurophysiol 88, 2430-2444
   Abstract »    Full Text »    PDF »
Neuronal Premotor Networks Involved in Eyelid Responses: Retrograde Transneuronal Tracing with Rabies Virus from the Orbicularis Oculi Muscle in the Rat.
S. Morcuende, J.-M. Delgado-Garcia, and G. Ugolini (2002)
J. Neurosci. 22, 8808-8818
   Abstract »    Full Text »    PDF »
Monitoring Kinetic and Frequency-Domain Properties of Eyelid Responses in Mice With Magnetic Distance Measurement Technique.
S.K.E. Koekkoek, W. L. Den Ouden, G. Perry, S. M. Highstein, and C. I. De Zeeuw (2002)
J Neurophysiol 88, 2124-2133
   Abstract »    Full Text »    PDF »
Psychological functions of the cerebellum..
D. B. Katz and J. E. Steinmetz (2002)
Behav Cogn Neurosci Rev 1, 229-241
   Abstract »    PDF »
Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles.
M. Ito (2001)
Physiol Rev 81, 1143-1195
   Abstract »    Full Text »    PDF »
A Mechanism for Savings in the Cerebellum.
J. F. Medina, K. S. Garcia, and M. D. Mauk (2001)
J. Neurosci. 21, 4081-4089
   Abstract »    Full Text »    PDF »
Latent Acquisition of Timed Responses in Cerebellar Cortex.
T. Ohyama and M. D. Mauk (2001)
J. Neurosci. 21, 682-690
   Abstract »    Full Text »    PDF »
Timing Mechanisms in the Cerebellum: Testing Predictions of a Large-Scale Computer Simulation.
J. F. Medina, K. S. Garcia, W. L. Nores, N. M. Taylor, and M. D. Mauk (2000)
J. Neurosci. 20, 5516-5525
   Abstract »    Full Text »    PDF »
Cerebello-Olivary and Lateral (Accessory) Cuneate Degeneration in a Juvenile American Miniature Horse.
J. Fox, R. Duncan, P. Friday, B. Klein, and W. Scarratt (2000)
Vet. Pathol. 37, 271-274
   Abstract »    Full Text »    PDF »
Localization of a Short-Term Memory in Drosophila.
T. Zars, M. Fischer, R. Schulz, and M. Heisenberg (2000)
Science 288, 672-675
   Abstract »    Full Text »
Cerebellar Cortex Lesions Prevent Acquisition of Conditioned Eyelid Responses.
K. S. Garcia, P. M. Steele, and M. D. Mauk (1999)
J. Neurosci. 19, 10940-10947
   Abstract »    Full Text »    PDF »
Simulations of Cerebellar Motor Learning: Computational Analysis of Plasticity at the Mossy Fiber to Deep Nucleus Synapse.
J. F. Medina and M. D. Mauk (1999)
J. Neurosci. 19, 7140-7151
   Abstract »    Full Text »    PDF »
Intracellular Correlates of Acquisition and Long-Term Memory of Classical Conditioning in Purkinje Cell Dendrites in Slices of Rabbit Cerebellar Lobule HVI.
B. G. Schreurs, P. A. Gusev, D. Tomsic, D. L. Alkon, and T. Shi (1998)
J. Neurosci. 18, 5498-5507
   Abstract »    Full Text »    PDF »
Role of Monkey Cerebellar Nuclei in Skill for Sequential Movement.
X. Lu, O. Hikosaka, and S. Miyachi (1998)
J Neurophysiol 79, 2245-2254
   Abstract »    Full Text »    PDF »
N-Methyl-D-Aspartate Receptors in Associative Eyeblink Conditioning: Both MK-801 and Phencyclidine Produce Task- and Dose-Dependent Impairments.
L. T. Thompson and J. F. Disterhoft (1997)
J. Pharmacol. Exp. Ther. 281, 928-940
   Abstract »    Full Text »
Dendritic Excitability Microzones and Occluded Long-Term Depression After Classical Conditioning of the Rabbit's Nictitating Membrane Response.
B. G. Schreurs, D. Tomsic, P. A. Gusev, and D. L. Alkon (1997)
J Neurophysiol 77, 86-92
   Abstract »    Full Text »    PDF »
Prediction and preparation, fundamental functions of the cerebellum..
E Courchesne and G Allen (1997)
Learn. Mem. 4, 1-35
   PDF »
Reversible inactivation of the cerebellar interpositus nucleus completely prevents acquisition of the classically conditioned eye-blink response..
D J Krupa and R F Thompson (1997)
Learn. Mem. 3, 545-556
   Abstract »    PDF »
A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum..
M D Mauk and N H Donegan (1997)
Learn. Mem. 4, 130-158
   Abstract »    PDF »
Functional Mapping of Human Learning: A Positron Emission Tomography Activation Study of Eyeblink Conditioning.
T. A. Blaxton, T. A. Zeffiro, J. D. E. Gabrieli, S. Y. Bookheimer, M. C. Carrillo, W. H. Theodore, and J. F. Disterhoft (1996)
J. Neurosci. 16, 4032-4040
   Abstract »    Full Text »    PDF »
Hypoplasia of the Cerebellar Vermis and Cognitive Deficits in Survivors of Childhood Leukemia.
K. T. Ciesielski, R. Yanofsky, R. N. Ludwig, D. E. Hill, B. L. Hart, R. S. Astur, and T. Snyder (1994)
Arch Neurol 51, 985-993
   Abstract »    PDF »
Activation of a cerebellar output nucleus during cognitive processing.
S. Kim, K Ugurbil, and P. Strick (1994)
Science 265, 949-951
   Abstract »    PDF »
Sensorimotor skill learning in amnesia: additional evidence for the neural basis of nondeclarative memory..
D Tranel, A R Damasio, H Damasio, and J P Brandt (1994)
Learn. Mem. 1, 165-179
   Abstract »    PDF »
Localization of a memory trace in the mammalian brain.
D. Krupa, J. Thompson, and R. Thompson (1993)
Science 260, 989-991
   Abstract »    PDF »
Stress-induced facilitation of classical conditioning.
T. Shors, C Weiss, and R. Thompson (1992)
Science 257, 537-539
   Abstract »    PDF »
An Emerging Concept: The Cerebellar Contribution to Higher Function.
J. D. Schmahmann (1991)
Arch Neurol 48, 1178-1187
   Abstract »    PDF »
Imaging of memory-specific changes in the distribution of protein kinase C in the hippocampus.
J. Olds, M. Anderson, D. McPhie, L. Staten, and D. Alkon (1989)
Science 245, 866-869
   Abstract »    PDF »
Cerebellar Structure in Autism.
G. R. Gaffney, L. Y. Tsai, S. Kuperman, and S. Minchin (1987)
Arch Pediatr Adolesc Med 141, 1330-1332
   Abstract »    PDF »
Abnormal Neuroanatomy in a Nonretarded Person With Autism: Unusual Findings With Magnetic Resonance Imaging.
E. Courchesne, J. R. Hesselink, T. L. Jernigan, and R. Yeung-Courchesne (1987)
Arch Neurol 44, 335-341
   Abstract »    PDF »
The neurobiology of learning and memory.
R. Thompson (1986)
Science 233, 941-947
   Abstract »    PDF »
Cerebellar vermis: essential for long-term habituation of the acoustic startle response.
R. Leaton and W. Supple Jr (1986)
Science 232, 513-515
   Abstract »    PDF »
Cerebellar cortical inhibition and classical eyeblink conditioning.
S. Bao, L. Chen, J. J. Kim, and R. F. Thompson (2002)
PNAS 99, 1592-1597
   Abstract »    Full Text »    PDF »
Cerebellar Cortical AMPA-Kainate Receptor Blockade Prevents Performance of Classically Conditioned Nictitating Membrane Responses.
P. J. E. Attwell, S. Rahman, M. Ivarsson, and C. H. Yeo (1999)
J. Neurosci. 19, RC45
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)