Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 January 1984:
Vol. 223. no. 4633, pp. 249 - 255
DOI: 10.1126/science.6322295
Prev | Table of Contents | Next

Articles

Science, Vol 223, Issue 4633, 249-255
Copyright © 1984 by American Association for the Advancement of Science

articles

Amphiphilic secondary structure: design of peptide hormones

ET Kaiser and FJ Kezdy

Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
C-terminal Elongation of Growth-blocking Peptide Enhances Its Biological Activity and Micelle Binding Affinity.
Y. Umetsu, T. Aizawa, K. Muto, H. Yamamoto, M. Kamiya, Y. Kumaki, M. Mizuguchi, M. Demura, Y. Hayakawa, and K. Kawano (2009)
J. Biol. Chem. 284, 29625-29634
   Abstract »    Full Text »    PDF »
Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10.
J. L. Varga, A. V. Schally, J. E. Horvath, M. Kovacs, G. Halmos, K. Groot, G. L. Toller, Z. Rekasi, and M. Zarandi (2004)
PNAS 101, 1708-1713
   Abstract »    Full Text »    PDF »
Importance of the Amino Terminus in Secretin Family G Protein-coupled Receptors: INTRINSIC PHOTOAFFINITY LABELING ESTABLISHES INITIAL DOCKING CONSTRAINTS FOR THE CALCITONIN RECEPTOR.
M. Dong, D. I. Pinon, R. F. Cox, and L. J. Miller (2004)
J. Biol. Chem. 279, 1167-1175
   Abstract »    Full Text »    PDF »
Synthesis and biological evaluation of antagonists of growth hormone-releasing hormone with high and protracted in vivo activities.
J. L. Varga, A. V. Schally, V. J. Csernus, M. Zarandi, G. Halmos, K. Groot, and Z. Rekasi (1999)
PNAS 96, 692-697
   Abstract »    Full Text »    PDF »
Isolation and Characterization of Pediocin AcH Chimeric Protein Mutants with Altered Bactericidal Activity.
K. W. Miller, R. Schamber, O. Osmanagaoglu, and B. Ray (1998)
Appl. Envir. Microbiol. 64, 1997-2005
   Abstract »    Full Text »    PDF »
Association-induced folding of globular proteins.
V. N. Uversky, D. J. Segel, S. Doniach, and A. L. Fink (1998)
PNAS 95, 5480-5483
   Abstract »    Full Text »    PDF »
Conformation-dependent Antibacterial Activity of the Naturally Occurring Human Peptide LL-37.
J. Johansson, G. H. Gudmundsson, M. E. Rottenberg, K. D. Berndt, and B. Agerberth (1998)
J. Biol. Chem. 273, 3718-3724
   Abstract »    Full Text »    PDF »
Mode matches and their locations in the hydrophobic free energy sequences of peptide ligands and their receptor eigenfunctions.
A. J. Mandell, K. A. Selz, and M. F. Shlesinger (1997)
PNAS 94, 13576-13581
   Abstract »    Full Text »    PDF »
Dimerization of the Highly Conserved Light Chain Shared by Dynein and Myosin V.
S. E. Benashski, A. Harrison, R. S. Patel-King, and S. M. King (1997)
J. Biol. Chem. 272, 20929-20935
   Abstract »    Full Text »    PDF »
Full Activation of Chimeric Receptors by Hybrids between Parathyroid Hormone and Calcitonin. EVIDENCE FOR A COMMON PATTERN OF LIGAND-RECEPTOR INTERACTION.
C. Bergwitz, T. J. Gardella, M. R. Flannery, J. T. Potts Jr., H. M. Kronenberg, S. R. Goldring, and H. Juppner (1996)
J. Biol. Chem. 271, 26469-26472
   Abstract »    Full Text »    PDF »
Saturation Mutagenesis of Human Interleukin-3.
P. O. Olins, S. C. Bauer, S. Braford-Goldberg, K. Sterbenz, J. O. Polazzi, M. H. Caparon, B. K. Klein, A. M. Easton, K. Paik, J. A. Klover, et al. (1995)
J. Biol. Chem. 270, 23754-23760
   Abstract »    Full Text »    PDF »
Molecular analysis of the gamma heavy chain of Chlamydomonas flagellar outer-arm dynein.
C. Wilkerson, S. King, and G. Witman (1994)
J. Cell Sci. 107, 497-506
   Abstract »    PDF »
Metal ion-dependent modulation of the dynamics of a designed protein.
T. Handel, S. Williams, and W. DeGrado (1993)
Science 261, 879-885
   Abstract »    PDF »
Design of DNA-binding peptides based on the leucine zipper motif.
K. O'Neil, R. Hoess, and W. DeGrado (1990)
Science 249, 774-778
   Abstract »    PDF »
Protein design, a minimalist approach.
W. DeGrado, Z. Wasserman, and J. Lear (1989)
Science 243, 622-628
   Abstract »    PDF »
Peptide and protein synthesis by segment synthesis-condensation.
E. Kaiser, H Mihara, G. Laforet, J. Kelly, L Walters, M. Findeis, and T Sasaki (1989)
Science 243, 187-192
   Abstract »    PDF »
Characterization of a helical protein designed from first principles.
L Regan and W. DeGrado (1988)
Science 241, 976-978
   Abstract »    PDF »
Computers in molecular biology: current applications and emerging trends.
C DeLisi (1988)
Science 240, 47-52
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)