Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 January 1984:
Vol. 223. no. 4632, pp. 169 - 171
DOI: 10.1126/science.6318317
Prev | Table of Contents | Next

Articles

Science, Vol 223, Issue 4632, 169-171
Copyright © 1984 by American Association for the Advancement of Science

articles

Nicotine is chemotactic for neutrophils and enhances neutrophil responsiveness to chemotactic peptides

N Totti 3rd, KT McCusker, EJ Campbell, GL Griffin, and RM Senior

Neutrophils contribute to chronic bronchitis and pulmonary emphysema associated with cigarette smoking. Nicotine was found to be chemotactic for human neutrophils but not monocytes, with a peak activity at approximately 31 micromolar. In lower concentrations (comparable to those in smokers' plasma), nicotine enhanced the response of neutrophils to two chemotactic peptides. In contrast to most other chemoattractants for neutrophils, however, nicotine did not affect degranulation or superoxide production. Nicotine thus may promote inflammation and consequent lung injury in smokers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{alpha}3{alpha}5{beta}2-Nicotinic Acetylcholine Receptor Contributes to the Wound Repair of the Respiratory Epithelium by Modulating Intracellular Calcium in Migrating Cells.
J.-M. Tournier, K. Maouche, C. Coraux, J.-M. Zahm, I. Cloez-Tayarani, B. Nawrocki-Raby, A. Bonnomet, H. Burlet, F. Lebargy, M. Polette, et al. (2006)
Am. J. Pathol. 168, 55-68
   Abstract »    Full Text »    PDF »
The Ras/Raf-1/MEK1/ERK Signaling Pathway Coupled to Integrin Expression Mediates Cholinergic Regulation of Keratinocyte Directional Migration.
A. I. Chernyavsky, J. Arredondo, E. Karlsson, I. Wessler, and S. A. Grando (2005)
J. Biol. Chem. 280, 39220-39228
   Abstract »    Full Text »    PDF »
Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes.
A. I. Chernyavsky, J. Arredondo, L. M. Marubio, and S. A. Grando (2004)
J. Cell Sci. 117, 5665-5679
   Abstract »    Full Text »    PDF »
Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-{kappa}B.
S. Iho, Y. Tanaka, R. Takauji, C. Kobayashi, I. Muramatsu, H. Iwasaki, K. Nakamura, Y. Sasaki, K. Nakao, and T. Takahashi (2003)
J. Leukoc. Biol. 74, 942-951
   Abstract »    Full Text »    PDF »
Selectin-dependent rolling and adhesion of leukocytes in nicotine-exposed microvessels of lung allografts.
L. Sikora, S. P. Rao, and P. Sriramarao (2003)
Am J Physiol Lung Cell Mol Physiol 285, L654-L663
   Abstract »    Full Text »    PDF »
Nicotine Strongly Activates Dendritic Cell-Mediated Adaptive Immunity: Potential Role for Progression of Atherosclerotic Lesions.
A. Aicher, C. Heeschen, M. Mohaupt, J. P. Cooke, A. M. Zeiher, and S. Dimmeler (2003)
Circulation 107, 604-611
   Abstract »    Full Text »    PDF »
Increased Expression of Transforming Growth Factor-{beta}1 in Small Airway Epithelium from Tobacco Smokers and Patients with Chronic Obstructive Pulmonary Disease (COPD).
H. TAKIZAWA, M. TANAKA, K. TAKAMI, T. OHTOSHI, K. ITO, M. SATOH, Y. OKADA, F. YAMASAWA, K. NAKAHARA, and A. UMEDA (2001)
Am. J. Respir. Crit. Care Med. 163, 1476-1483
   Abstract »    Full Text »
Interferon {gamma} Induction of Pulmonary Emphysema in the Adult Murine Lung.
Z. Wang, T. Zheng, Z. Zhu, R. J. Homer, R. J. Riese, H. A. Chapman Jr., S. D. Shapiro, and J. A. Elias (2000)
J. Exp. Med. 192, 1587-1600
   Abstract »    Full Text »    PDF »
Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers.
H. Takizawa, M. Tanaka, K. Takami, T. Ohtoshi, K. Ito, M. Satoh, Y. Okada, F. Yamasawa, and A. Umeda (2000)
Am J Physiol Lung Cell Mol Physiol 278, L906-L913
   Abstract »    Full Text »    PDF »
Chronic Obstructive Pulmonary Disease . Inflammation of Small Airways and Lung Parenchyma.
M. G. COSIO and A. GUERASSIMOV (1999)
Am. J. Respir. Crit. Care Med. 160, S21-25
   Abstract »    Full Text »    PDF »
Neutrophils and Protease/Antiprotease Imbalance.
R. A. STOCKLEY (1999)
Am. J. Respir. Crit. Care Med. 160, S49-52
   Abstract »    Full Text »    PDF »
Chlorination of Guanosine and Other Nucleosides by Hypochlorous Acid and Myeloperoxidase of Activated Human Neutrophils. CATALYSIS BY NICOTINE AND TRIMETHYLAMINE.
M. Masuda, T. Suzuki, M. D. Friesen, J.-L. Ravanat, J. Cadet, B. Pignatelli, H. Nishino, and H. Ohshima (2001)
J. Biol. Chem. 276, 40486-40496
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)