Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 January 1984:
Vol. 223. no. 4631, pp. 63 - 66
DOI: 10.1126/science.6318314
Prev | Table of Contents | Next

Articles

Science, Vol 223, Issue 4631, 63-66
Copyright © 1984 by American Association for the Advancement of Science

articles

Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase

G Naharro, KC Robbins, and EP Reddy

The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region of P70gag-fgr is closely related to the tyrosine-specific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Novel Hybrid Open Reading Frame Formed by Multiple Cellular Gene Transductions by a Plant Long Terminal Repeat Retroelement.
N. Elrouby and T. E. Bureau (2001)
J. Biol. Chem. 276, 41963-41968
   Abstract »    Full Text »    PDF »
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.
P Liu, S. Tarle, A Hajra, D. Claxton, P Marlton, M Freedman, M. Siciliano, and F. Collins (1993)
Science 261, 1041-1044
   Abstract »    PDF »
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
A Bellacosa, Testa JR, S. Staal, and P. Tsichlis (1991)
Science 254, 274-277
   Abstract »    PDF »
A method to identify protein sequences that fold into a known three-dimensional structure.
J. Bowie, R Luthy, and D Eisenberg (1991)
Science 253, 164-170
   Abstract »    PDF »
A novel putative tyrosine kinase receptor encoded by the eph gene.
H Hirai, Y Maru, K Hagiwara, J Nishida, and F Takaku (1987)
Science 238, 1717-1720
   Abstract »    PDF »
Molecular Characterization of the Human trk Oncogene.
D. Martin-Zanca, G. Mitra, L.K. Long, and M. Barbacid (1986)
Cold Spring Harb Symp Quant Biol 51, 983-992
   Abstract »    PDF »
Location of the c-yes gene on the human chromosome and its expression in various tissues.
K Semba, Y Yamanashi, M Nishizawa, J Sukegawa, M Yoshida, M Sasaki, T Yamamoto, and K Toyoshima (1985)
Science 227, 1038-1040
   Abstract »    PDF »
Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera.
H. Niman, R. Houghten, and D. Bowen-Pope (1984)
Science 226, 701-703
   Abstract »    PDF »
A common onc gene sequence transduced by avian carcinoma virus MH2 and by murine sarcoma virus 3611.
N. Kan, C. Flordellis, G. Mark, P. Duesberg, and T. Papas (1984)
Science 223, 813-816
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)