Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 January 1984:
Vol. 223. no. 4631, pp. 58 - 61
DOI: 10.1126/science.6318313
Prev | Table of Contents | Next

Articles

Science, Vol 223, Issue 4631, 58-61
Copyright © 1984 by American Association for the Advancement of Science

articles

Inhibition of human acute lymphoblastic leukemia cells by immunotoxins: potentiation by chloroquine

S Ramakrishnan and LL Houston

Immunotoxins containing pokeweed antiviral protein and monoclonal antibodies against human T cells or human transferrin receptor efficiently killed acute lymphoblastic leukemia cells. Chloroquine specifically enhanced the rate of protein synthesis inhibition by immunotoxin. Depending on its concentration, chloroquine (10 to 100 micromolar) reduced by up to 65-fold the amount of immunotoxin required to inhibit protein synthesis in the target cells 50 percent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Apoptotic Ligands TRAIL, TWEAK, and Fas Ligand Mediate Monocyte Death Induced by Autologous Lupus T Cells.
M. J. Kaplan, E. E. Lewis, E. A. Shelden, E. Somers, R. Pavlic, W. J. McCune, and B. C. Richardson (2002)
J. Immunol. 169, 6020-6029
   Abstract »    Full Text »    PDF »
Construction, Expression, and Characterization of BD1-G28-5 sFv, a Single-chain Anti-CD40 Immunotoxin Containing the Ribosome-inactivating Protein Bryodin 1.
J. A. Francisco, S. L. Gawlak, and C. B. Siegall (1997)
J. Biol. Chem. 272, 24165-24169
   Abstract »    Full Text »    PDF »
Redesigning nature's poisons to create anti-tumor reagents.
E. Vitetta, R. Fulton, R. May, M Till, and J. Uhr (1987)
Science 238, 1098-1104
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)