Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 December 1983:
Vol. 222. no. 4629, pp. 1239 - 1242
DOI: 10.1126/science.6606228
Prev | Table of Contents | Next

Articles

Science, Vol 222, Issue 4629, 1239-1242
Copyright © 1983 by American Association for the Advancement of Science

articles

Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes

SC Meuer, DA Cooper, JC Hodgdon, RE Hussey, KA Fitzgerald, SF Schlossman, and EL Reinherz

Human T cell clones and monoclonal antibodies directed at their surface structures were used to define the receptor for the antigen and major histocompatibility complex on inducer T lymphocytes. The results indicated that the receptor is a single complex consisting of the monomorphic T3 molecule with a molecular weight of 20,000 to 25,000 and a clonotypic disulfide linked heterodimer Ti with a molecular weight of 90,000. Sepharose-bound monoclonal antibodies (anti-Ti4 or anti-T3) to the receptor could activate clonal proliferation and inducer function for B cell immunoglobulin secretion and thus substitute for the appropriate combination of major histocompatibility complex gene product and specific antigen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polymorphisms in the CD3Z Gene Influence TCR{zeta} Expression in Systemic Lupus Erythematosus Patients and Healthy Controls.
C. L. Gorman, A. I. Russell, Z. Zhang, D. Cunninghame Graham, A. P. Cope, and T. J. Vyse (2008)
J. Immunol. 180, 1060-1070
   Abstract »    Full Text »    PDF »
T cell receptor {zeta} reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor {alpha}.
J. M. Clark, A. E. Annenkov, M. Panesar, P. Isomaki, Y. Chernajovsky, and A. P. Cope (2004)
PNAS 101, 1696-1701
   Abstract »    Full Text »    PDF »
Involvement of the TCR C{beta} FG Loop in Thymic Selection and T Cell Function.
T. Sasada, M. Touma, H.-C. Chang, L. K. Clayton, J.-h. Wang, and E. L. Reinherz (2002)
J. Exp. Med. 195, 1419-1431
   Abstract »    Full Text »    PDF »
CD2 molecules redistribute to the uropod during T cell scanning: Implications for cellular activation and immune surveillance.
E. V. Tibaldi, R. Salgia, and E. L. Reinherz (2002)
PNAS 99, 7582-7587
   Abstract »    Full Text »    PDF »
The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr {zeta} Chain.
H. Kirchgessner, J. Dietrich, J. Scherer, P. Isomaki, V. Korinek, I. Hilgert, E. Bruyns, A. Leo, A. P. Cope, and B. Schraven (2001)
J. Exp. Med. 193, 1269-1284
   Abstract »    Full Text »    PDF »
T cell activation responses are differentially regulated during clinorotation and in spaceflight.
B. B. HASHEMI, J. E. PENKALA, C. VENS, H. HULS, M. CUBBAGE, and C. F. SAMS (1999)
FASEB J 13, 2071-2082
   Abstract »    Full Text »
Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes.
C Milanese, N. Richardson, and E. Reinherz (1986)
Science 231, 1118-1122
   Abstract »    PDF »
Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.
J Ritz, T. Campen, R. Schmidt, H. Royer, T Hercend, R. Hussey, and E. Reinherz (1985)
Science 228, 1540-1543
   Abstract »    PDF »
Chromosomal location of human T-cell receptor gene Ti beta.
P. Barker, F. Ruddle, H. Royer, O Acuto, and E. Reinherz (1984)
Science 226, 348-349
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)