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Science 9 December 1983:
Vol. 222. no. 4628, pp. 1128 - 1129
DOI: 10.1126/science.6316503
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Articles

Science, Vol 222, Issue 4628, 1128-1129
Copyright © 1983 by American Association for the Advancement of Science

articles

Effect of prior immunization on induction of cervial cancer in mice by herpes simplex virus type 2

WB Wentz, AD Heggie, DD Anthony, and JW Reagan

Previous studies at this laboratory showed that repeated application of inactivated herpes simplex virus type 2 to the mouse cevix produced premalignant and malignant lesions. In the present study mice were inoculated with inactivated herpes simplex virus type 2 or control solution and Freund's adjuvant by intraperitoneal and subcuaneous routes before exposure of the cervix to inactivated virus. It appears that immunization with inactivated virus conferred a protection against the induction of cervical carcinoma.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Resistance of Mouse Nasopharynx to Induction of Neoplasia by Herpes Simplex Virus.
A. D. Heggie and Y.-S. Fu (1988)
Arch Otolaryngol Head Neck Surg 114, 788-790
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