Science 18 November 1983: Vol. 222. no. 4625, pp. 809 - 814 DOI: 10.1126/science.6356363

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Articles

Autocrine Human Growth Hormone Stimulates Oncogenicity of Endometrial Carcinoma Cells.

V. Pandey, J. K. Perry, K. M. Mohankumar, X.-J. Kong, S.-M. Liu, Z.-S. Wu, M. D. Mitchell, T. Zhu, and P. E. Lobie (2008)
Endocrinology 149, 3909-3919
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Every-Other-Day Feeding on Prolactin Regulatory Mechanism in Transgenic Human Growth Hormone Mice.

V. Jimenez-Ortega, M. M. Masternak, J. A. Panici, Z. Wang, A. Bartke, and A. I. Esquifino (2008)
Experimental Biology and Medicine 233, 434-438
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The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer.

D. Hanahan, E. F. Wagner, and R. D. Palmiter (2007)
Genes & Dev. 21, 2258-2270
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Renal Bone Morphogenetic Protein-7 Protects against Diabetic Nephropathy.

S. Wang, M. de Caestecker, J. Kopp, G. Mitu, J. LaPage, and R. Hirschberg (2006)
J. Am. Soc. Nephrol. 17, 2504-2512
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Expression of mutant human cystathionine {beta}-synthase rescues neonatal lethality but not homocystinuria in a mouse model.

L. Wang, X. Chen, B. Tang, X. Hua, A. Klein-Szanto, and W. D. Kruger (2005)
Hum. Mol. Genet. 14, 2201-2208
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Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis.

S. K. Frankel, B. M. Moats-Staats, C. D. Cool, M. W. Wynes, A. D. Stiles, and D. W. H. Riches (2005)
Am J Physiol Lung Cell Mol Physiol 288, L805-L812
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Roles of the Lactogens and Somatogens in Perinatal and Postnatal Metabolism and Growth: Studies of a Novel Mouse Model Combining Lactogen Resistance and Growth Hormone Deficiency.

D. Fleenor, J. Oden, P. A. Kelly, S. Mohan, S. Alliouachene, M. Pende, S. Wentz, J. Kerr, and M. Freemark (2005)
Endocrinology 146, 103-112
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Role of Growth Hormone (GH) in Liver Regeneration.

P. A. Pennisi, J. J. Kopchick, S. Thorgeirsson, D. LeRoith, and S. Yakar (2004)
Endocrinology 145, 4748-4755
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Growth Hormone and Epidermal Growth Factor in Salivary Glands of Giant and Dwarf Transgenic Mice.

W. G. Young, G. O. Ramirez-Yanez, T. J. Daley, J. R. Smid, K. T. Coshigano, J. J. Kopchick, and M. J. Waters (2004)
J. Histochem. Cytochem. 52, 1191-1197
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Modulation of Cystathionine {beta}-Synthase Level Regulates Total Serum Homocysteine in Mice.

L. Wang, K.-H. Jhee, X. Hua, P. M. DiBello, D. W. Jacobsen, and W. D. Kruger (2004)
Circ. Res. 94, 1318-1324
 |  Abstract »  |  Full Text »  |  PDF »

Lymphoid Tissue and Emphysema in the Lungs of Transgenic Mice Inducibly Expressing Tumor Necrosis Factor-{alpha}.

B. R. Vuillemenot, J. F. Rodriguez, and G. W. Hoyle (2004)
Am. J. Respir. Cell Mol. Biol. 30, 438-448
 |  Abstract »  |  Full Text »  |  PDF »

Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management.

A. Colao, D. Ferone, P. Marzullo, and G. Lombardi (2004)
Endocr. Rev. 25, 102-152
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.

K. C. Leung, N. Doyle, M. Ballesteros, K. Sjogren, C. K. W. Watts, T. H. Low, G. M. Leong, R. J. M. Ross, and K. K. Y. Ho (2003)
PNAS 100, 1016-1021
 |  Abstract »  |  Full Text »  |  PDF »

Conditional AC type VI expression in the heart: relevant insights into function of inducible target gene expression.

P. Most, A. Remppis, and H. A Katus (2002)
Cardiovasc Res 56, 181-183
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Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone Signaling.

C. J. Greenhalgh, D. Metcalf, A. L. Thaus, J. E. Corbin, R. Uren, P. O. Morgan, L. J. Fabri, J.-G. Zhang, H. M. Martin, T. A. Willson, et al. (2002)
J. Biol. Chem. 277, 40181-40184
 |  Abstract »  |  Full Text »  |  PDF »

Growth Enhancement in Suppressor of Cytokine Signaling 2 (SOCS-2)-Deficient Mice Is Dependent on Signal Transducer and Activator of Transcription 5b (STAT5b).

C. J. Greenhalgh, P. Bertolino, S. L. Asa, D. Metcalf, J. E. Corbin, T. E. Adams, H. W. Davey, N. A. Nicola, D. J. Hilton, and W. S. Alexander (2002)
Mol. Endocrinol. 16, 1394-1406
 |  Abstract »  |  Full Text »  |  PDF »

Models of Growth Hormone and IGF-1 Deficiency: Applications to Studies of Aging Processes and Life-Span Determination.

C. S. Carter, M. M. Ramsey, R. L. Ingram, A. B. Cashion, W. T. Cefalu, Z.Q. Wang, and W. E. Sonntag (2002)
J. Gerontol. A Biol. Sci. Med. Sci. 57, B177-188
 |  Abstract »  |  Full Text »

A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymenathermophila.

Y. Shang, X. Song, J. Bowen, R. Corstanje, Y. Gao, J. Gaertig, and M. A. Gorovsky (2002)
PNAS 99, 3734-3739
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Human Stanniocalcin Affects Growth and Reproduction in Transgenic Mice.

R. Varghese, A. D. Gagliardi, P. E. Bialek, S.-P. Yee, G. F. Wagner, and G. E. Dimattia (2002)
Endocrinology 143, 868-876
 |  Abstract »  |  Full Text »  |  PDF »

Human glucagon gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression.

M. Nian, J. Gu, D. M. Irwin, and D. J. Drucker (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R173-R183
 |  Abstract »  |  Full Text »  |  PDF »

Reproductive Deficiencies in Transgenic Mice Expressing the Rat Inhibin {alpha}-Subunit Gene.

B.-N. Cho, M. L. McMullen, L. Pei, C. J. Yates, and K. E. Mayo (2001)
Endocrinology 142, 4994-5004
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Gonadal Pathologies in Transgenic Mice Expressing the Rat Inhibin {alpha}-Subunit.

M. L. McMullen, B.-N. Cho, C. J. Yates, and K. E. Mayo (2001)
Endocrinology 142, 5005-5014
 |  Abstract »  |  Full Text »  |  PDF »

The Retinoblastoma Gene Regulates Somatic Growth during Mouse Development.

A. Yu. Nikitin, B. Shan, A. Flesken-Nikitin, K.-H. Chang, and W.-H. Lee (2001)
Cancer Res. 61, 3110-3118
 |  Abstract »  |  Full Text »

The Somatomedin Hypothesis: 2001.

D. Le Roith, C. Bondy, S. Yakar, J.-L. Liu, and A. Butler (2001)
Endocr. Rev. 22, 53-74
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Morphological Changes in the Kidney of Dogs Chronically Exposed to Exogenous Growth Hormone.

S. Molon-Noblot, P. Laroque, S. Prahalada, L. G. Stabinski, C. P. Peter, P. Duprat, and M. J. Van Zwieten (2000)
Toxicol Pathol 28, 510-517
 |  Abstract »  |  PDF »

An Alu Element from the K18 Gene Confers Position-independent Expression in Transgenic Mice.

D. A. Willoughby, A. Vilalta, and R. G. Oshima (2000)
J. Biol. Chem. 275, 759-768
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Xenopus laevis growth hormone stimulates growth of tadpoles and frogs.

H. Huang and D. D. Brown (2000)
PNAS 97, 190-194
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Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion.

Y. Takarada, Y. Nakamura, S. Aruga, T. Onda, S. Miyazaki, and N. Ishii (2000)
J Appl Physiol 88, 61-65
 |  Abstract »  |  Full Text »  |  PDF »

Pituitary Hormones as Neurotrophic Signals: Update on Hypothalamic Differentiation in Genetic Models of Altered Feedback.

C. J. Phelps and D. L. Hurley (1999)
Experimental Biology and Medicine 222, 39-58
 |  Abstract »  |  Full Text »

Vitamin A–Sensitive Tissues in Transgenic Mice Expressing High Levels of Human Cellular Retinol-Binding Protein Type I Are Not Altered Phenotypically.

G. Trøen, W. Eskild, S. H. Fromm, L. M. De Luca, D. E. Ong, S. A. Wardlaw, S. Reppe, and R. Blomhoff (1999)
J. Nutr. 129, 1621-1627
 |  Abstract »  |  Full Text »

Transgenic Models to Study Gonadotropin Function: The Role of Follicle-Stimulating Hormone in Gonadal Growth and Tumorigenesis.

T. R. Kumar, G. Palapattu, P. Wang, T. K. Woodruff, I. Boime, M. C. Byrne, and M. M. Matzuk (1999)
Mol. Endocrinol. 13, 851-865
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Adenovirus-mediated regulable target gene expression in vivo.

M. M. Burcin, G. Schiedner, S. Kochanek, S. Y. Tsai, and B. W. O'Malley (1999)
PNAS 96, 355-360
 |  Abstract »  |  Full Text »  |  PDF »

Derepression of human embryonic zeta -globin promoter by a locus-control region sequence.

B.-L. Huang, I. R. Fan-Chiang, S. C. Wen, H.-C. Koo, W. Y. Kao, N. R. Gavva, and C.-K. J. Shen (1998)
PNAS 95, 14669-14674
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus.

C. Costa, G. Solanes, J. Visa, and F. Bosch (1998)
FASEB J 12, 1455-1460
 |  Abstract »  |  Full Text »

Transgenic Mice Overexpressing the Complement Inhibitor Crry as a Soluble Protein Are Protected from Antibody-induced Glomerular Injury.

R. J. Quigg, C. He, A. Lim, D. Berthiaume, J. J. Alexander, D. Kraus, and V. Michael Holers (1998)
J. Exp. Med. 188, 1321-1331
 |  Abstract »  |  Full Text »  |  PDF »

Obesity and Insulin Resistance in Human Growth Hormone Transgenic Rats.

A. Ikeda, K.-T. Chang, Y. Matsumoto, Y. Furuhata, M. Nishihara, F. Sasaki, and M. Takahashi (1998)
Endocrinology 139, 3057-3063
 |  Abstract »  |  Full Text »  |  PDF »

Timing Is Everything in Life : Conditional Transgene Expression in the Cardiovascular System.

G. I. Fishman (1998)
Circ. Res. 82, 837-844
 |  Abstract »  |  Full Text »  |  PDF »

Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias.

H. Honda, H. Oda, T. Suzuki, T. Takahashi, O. N. Witte, K. Ozawa, T. Ishikawa, Y. Yazaki, and H. Hirai (1998)
Blood 91, 2067-2075
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Mouse Follistatin Causes Reproductive Defects in Transgenic Mice.

Q. Guo, T. R. Kumar, T. Woodruff, L. A. Hadsell, F. J. DeMayo, and M. M. Matzuk (1998)
Mol. Endocrinol. 12, 96-106
 |  Abstract »  |  Full Text »

Stimulatory Effect of Human, but not Bovine, Growth Hormone Expression on Numbers of Tuberoinfundibular Dopaminergic Neurons in Transgenic Mice.

C. J. Phelps and A. Bartke (1997)
Endocrinology 138, 2849-2855
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic studies with a keratin promoter-driven growth hormone transgene: Prospects for gene therapy.

X. Wang, S. Zinkel, K. Polonsky, and E. Fuchs (1997)
PNAS 94, 219-226
 |  Abstract »  |  Full Text »  |  PDF »

Allometric Engineering: An Experimental Test of the Causes of Interpopulational Differences in Performance.

B. Sinervo and R. B. Huey (1990)
Science 248, 1106-1109
 |  Abstract »  |  PDF »

Genetic engineering of livestock.

V. Pursel, C. Pinkert, K. Miller, D. Bolt, R. Campbell, R. Palmiter, R. Brinster, and R. Hammer (1989)
Science 244, 1281-1288
 |  Abstract »  |  PDF »

Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes..

D A Sweetser, E H Birkenmeier, P C Hoppe, D W McKeel, and J I Gordon (1988)
Genes & Dev. 2, 1318-1332
 |  Abstract »  |  PDF »

A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons.

A. Geller and X. Breakefield (1988)
Science 241, 1667-1669
 |  Abstract »  |  PDF »

Transgenic animals.

R Jaenisch (1988)
Science 240, 1468-1474
 |  Abstract »  |  PDF »

Dwarf mice produced by genetic ablation of growth hormone-expressing cells..

R R Behringer, L S Mathews, R D Palmiter, and R L Brinster (1988)
Genes & Dev. 2, 453-461
 |  Abstract »  |  PDF »

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.

S. Hofmann, D. Russell, M. Brown, J. Goldstein, and R. Hammer (1988)
Science 239, 1277-1281
 |  Abstract »  |  PDF »

An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice..

C A Pinkert, D M Ornitz, R L Brinster, and R D Palmiter (1987)
Genes & Dev. 1, 268-276
 |  Abstract »  |  PDF »

Studying plant development: an alternative to "spray and pray".

J. R. Warner (1987)
Genes & Dev. 1, 3-5
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A transgenic mouse model of the chronic hepatitis B surface antigen carrier state.

F. Chisari, C. Pinkert, D. Milich, P Filippi, A McLachlan, R. Palmiter, and R. Brinster (1985)
Science 230, 1157-1160
 |  Abstract »  |  PDF »

Use of Gene Transfer to Increase Animal Growth.

R.E. Hammer, R.L. Brinster, and R.D. Palmiter (1985)
Cold Spring Harb Symp Quant Biol 50, 379-387
 |  Abstract »  |  PDF »

Inducible and Developmental Control of Neuroendocrine Genes.

R.M. Evans, C. Weinberger, S. Hollenberg, L. Swanson, C. Nelson, and M.G. Rosenfeld (1985)
Cold Spring Harb Symp Quant Biol 50, 389-397
 |  Abstract »  |  PDF »

Elastase I Promoter Directs Expression of Human Growth Hormone and SV40 T Antigen Genes to Pancreatic Acinar Cells in Transgenic Mice.

D.M. Ornitz, R.D. Palmiter, A. Messing, R.E. Hammer, C.A. Pinkert, and R.L. Brinster (1985)
Cold Spring Harb Symp Quant Biol 50, 399-409
 |  Abstract »  |  PDF »

Prospects for human gene therapy.

W. Anderson (1984)
Science 226, 401-409
 |  Abstract »  |  PDF »

Specific expression of transferred genes:Foreign genes, which were transferred into mice, appear to be expressed according to more normal patterns of tissue distribution.

J. Marx (1983)
Science 222, 1001-1002
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Sustained Expression of Exendin-4 Does Not Perturb Glucose Homeostasis, beta -Cell Mass, or Food Intake in Metallothionein-Preproexendin Transgenic Mice.

L. Baggio, F. Adatia, T. Bock, P. L. Brubaker, and D. J. Drucker (2000)
J. Biol. Chem. 275, 34471-34477
 |  Abstract »  |  Full Text »  |  PDF »

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