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Science 11 November 1983:
Vol. 222. no. 4624, pp. 581 - 585
DOI: 10.1126/science.6685343
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Articles

Science, Vol 222, Issue 4624, 581-585
Copyright © 1983 by American Association for the Advancement of Science

articles

Homeostasis of the antibody response: immunoregulation by NK cells

LV Abruzzo and DA Rowley

When injected into mice, the synthetic double-stranded polynucleotide poly(inosinic) X poly(cytidylic) acid induces high natural killer (NK) cell activity within 4 to 12 hours. Induction of NK activity in mice immunized 2 or 3 days previously, or the addition of NK cells to cultures immunized in vitro 2 or 3 days previously, promotes early termination of the ongoing primary immunoglobulin M antibody response. A target for NK cells is a population of accessory cells that has interacted with antigen and is necessary for sustaining the antibody response. The inference is strong that NK cells induced normally by immunization also terminate the usual antibody response in vivo by elimination of antigen-exposed accessory cells.


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