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Science 4 November 1983:
Vol. 222. no. 4623, pp. 518 - 521
DOI: 10.1126/science.6623092
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Articles

Science, Vol 222, Issue 4623, 518-521
Copyright © 1983 by American Association for the Advancement of Science

articles

Extensive dendritic sprouting induced by close axotomy of central neurons in the lamprey

GF Hall and MJ Cohen

Massive dendritic sprouting was induced in identified giant reticulospinal neurons of the lamprey by axotomy close to the soma. An axonal lesion slightly farther from the cell body induced new growth from both dendrites and axon. The amount of new growth per cell was the same whether it originated from the dendrites alone or from axonal and dendritic compartments. The location of the axonal lesion therefore determines where, in the neuron, membrane is inserted to produce the new neurites. The dendritic tree of a differentiated vertebrate central neuron was shown to have sufficient plasticity to extend new growth for several millimeters beyond the normal dendritic domain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Staging of Neurofibrillary Degeneration Caused by Human Tau Overexpression in a Unique Cellular Model of Human Tauopathy.
G. F. Hall, V. M.-Y. Lee, G. Lee, and J. Yao (2001)
Am. J. Pathol. 158, 235-246
   Abstract »    Full Text »    PDF »
Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ.
G. F. Hall, J. Yao, and G. Lee (1997)
PNAS 94, 4733-4738
   Abstract »    Full Text »    PDF »
Directional specificity in the regeneration of lamprey spinal axons.
H. Yin, S. Mackler, and M. Selzer (1984)
Science 224, 894-896
   Abstract »    PDF »


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