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Science 28 October 1983:
Vol. 222. no. 4622, pp. 390 - 393
DOI: 10.1126/science.6414084
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Articles

Science, Vol 222, Issue 4622, 390-393
Copyright © 1983 by American Association for the Advancement of Science

articles

Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma

A ar-Rushdi, K Nishikura, J Erikson, R Watt, G Rovera, and CM Croce

Burkitt lymphoma cells carrying either a rearranged or unrearranged c-myc oncogene were examined with the use of probes from the 5' exon and for the second and third exon of the oncogene. The results indicate that the normal c-myc gene on chromosome 8 and the 5' noncoding and 3' coding segments of the c-myc oncogene separated by the chromosomal translocation are under different transcriptional control in the lymphoma cells. Burkitt lymphoma cells carrying a translocated but unrearranged c-myc oncogene express normal c-myc transcripts. In contrast, lymphoma cells carrying a c-myc gene rearranged head to head with the immunoglobulin constant mu region gene express c-myc transcripts lacking the normal untranslated leader.


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