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Science 14 October 1983:
Vol. 222. no. 4620, pp. 169 - 172
DOI: 10.1126/science.6623064
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Articles

Science, Vol 222, Issue 4620, 169-172
Copyright © 1983 by American Association for the Advancement of Science

articles

Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye

SD Bernal, TJ Lampidis, RM McIsaac, and LB Chen

Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.


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Cloning and Identification of Hepatocellular Carcinoma Down-regulated Mitochondrial Carrier Protein, a Novel Liver-specific Uncoupling Protein.
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Photo-Induced Inactivation of Protein Kinase Calpha by Dequalinium Inhibits Motility of Murine Melanoma Cells.
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Inhibition of Rat Colon Tumor Isograft Growth With Dequalinium Chloride.
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