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Science 23 September 1983:
Vol. 221. no. 4617, pp. 1310 - 1312
DOI: 10.1126/science.6351252
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Articles

Science, Vol 221, Issue 4617, 1310-1312
Copyright © 1983 by American Association for the Advancement of Science

articles

A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide

JP Burbach, GL Kovacs, D de Wied, JW van Nispen, and HM Greven

A peptide that accumulated as the major product during the proteolysis of arginine vasopressin by rat brain synaptic membranes was isolated and its structure was shown to be the hexapeptide pGlu-Asn-Cys(Cys)-Pro-Arg-Gly-NH2. When administered intracerebroventricularly in extremely low doses, this vasopressin fragment and its desglycinamide derivative facilitated memory consolidation in a passive avoidance situation. These vasopressin metabolites, which are devoid of pressor activity, constitute highly potent neuropeptides with selective effects on memory and related processes; they are activated via proteolytic processing of vasopressin by brain peptidases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intracellular Pathways of V1 and V2 Receptors Activated by Arginine Vasopressin in Rat Hippocampal Neurons.
T. Omura, J. Nabekura, and N. Akaike (1999)
J. Biol. Chem. 274, 32762-32770
   Abstract »    Full Text »    PDF »
In Vivo and In Vitro Evidence of Blood-Brain Barrier Transport of a Novel Cationic Arginine-Vasopressin Fragment 4-9 Analog.
S. Tanabe, Y. Shimohigashi, Y. Nakayama, T. Makino, T. Fujita, T. Nose, G. Tsujimoto, T. Yokokura, M. Naito, T. Tsuruo, et al. (1999)
J. Pharmacol. Exp. Ther. 290, 561-568
   Abstract »    Full Text »


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