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Science 16 September 1983:
Vol. 221. no. 4616, pp. 1201 - 1203
DOI: 10.1126/science.6612335
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Articles

Science, Vol 221, Issue 4616, 1201-1203
Copyright © 1983 by American Association for the Advancement of Science

articles

Membrane changes in a single photoreceptor cause associative learning in Hermissenda

J Farley, WG Richards, LJ Ling, E Liman, and DL Alkon

Single type B photoreceptors in intact, restrained Hermissenda were impaled with a microelectrode and exposed to either paired or unpaired presentations of light and depolarizing current to simulate natural stimulus effects during conditioning with light and rotation. Paired, but not unpaired, stimulus presentations produced cumulative depolarization and increased input resistance in type B cells. These membrane changes are similar to those observed after pairings of light and rotation are administered to either intact animals or isolated nervous systems or when light is paired with electrical stimulation of the vestibular system in isolated nervous systems. One and two days after treatment, pairing- and light-specific suppression of phototactic behavior was observed in recovered animals. These findings indicate that the membrane changes of type B cells produced by pairing light with current injections cause acquisition of the learned behavior.


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Protein synthesis-dependent memory and neuronal enhancement in Hermissenda are contingent on parameters of training and retention..
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Calcium-mediated reduction of ionic currents: a biophysical memory trace.
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Ca2+-dependent protein kinase injection in a photoreceptor mimics biophysical effects of associative learning.
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