Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 September 1983:
Vol. 221. no. 4616, pp. 1183 - 1185
DOI: 10.1126/science.6612332
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4616, 1183-1185
Copyright © 1983 by American Association for the Advancement of Science

articles

Altered activity patterns during development reduce neural tuning

DH Sanes and M Constantine-Paton

Neonatal mice were reared in an acoustic environment that repetitively entrained activity in a large proportion of primary auditory afferents during the period when the frequency tuning of auditory neurons normally develops. The tuning curves obtained from these mice were significantly broader than those of normally reared mice of the same age. This suggests that the normal frequency tuning of neurons was prevented or delayed by synchronizing the pattern of activity imposed on the auditory pathway.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Intensive training in adults refines A1 representations degraded in an early postnatal critical period.
X. Zhou and M. M. Merzenich (2007)
PNAS 104, 15935-15940
   Abstract »    Full Text »    PDF »
Critical Period Window for Spectral Tuning Defined in the Primary Auditory Cortex (A1) in the Rat.
E. de Villers-Sidani, E. F. Chang, S. Bao, and M. M. Merzenich (2007)
J. Neurosci. 27, 180-189
   Abstract »    Full Text »    PDF »
Evidence of Brain Overgrowth in the First Year of Life in Autism.
E. Courchesne, R. Carper, and N. Akshoomoff (2003)
JAMA 290, 337-344
   Abstract »    Full Text »    PDF »
Environmental Noise Retards Auditory Cortical Development.
E. F. Chang and M. M. Merzenich (2003)
Science 300, 498-502
   Abstract »    Full Text »    PDF »
Alterations in Frequency Coding and Activity Dependence of Excitability in Cultured Neurons of Drosophila Memory Mutants.
M.-L. Zhao and C.-F. Wu (1997)
J. Neurosci. 17, 2187-2199
   Abstract »    Full Text »    PDF »
Disruption of primary auditory cortex by synchronous auditory inputs during a critical period.
L. I. Zhang, S. Bao, and M. M. Merzenich (2002)
PNAS 99, 2309-2314
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)