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Science 9 September 1983:
Vol. 221. no. 4615, pp. 1070 - 1072
DOI: 10.1126/science.6308770
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Articles

Science, Vol 221, Issue 4615, 1070-1072
Copyright © 1983 by American Association for the Advancement of Science

articles

Vasoactive intestinal peptide alters membrane potential and cyclic nucleotide levels in retinal horizontal cells

EM Lasater, KJ Watling, and JE Dowling

Vasoactive intestinal peptide stimulated the synthesis of adenosine 3',5'-monophosphate in fractions of isolated carp horizontal cells. When applied extracellularly to isolated and cultured horizontal cells, the peptide also induced a slow depolarization (30 to 40 millivolts) accompanied by a decrease in membrane resistance. However, analogs of adenosine 3',5'-monophosphate applied extracellularly or intracellularly, and forscolin applied extracellularly, had no effect on the membrane potential of cultured horizontal cells, indicating that the induced depolarization was not related to the accumulation of adenosine 3',5'-monophosphate in these cells.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)