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Science 9 September 1983:
Vol. 221. no. 4615, pp. 1059 - 1061
DOI: 10.1126/science.6192502
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Articles

Science, Vol 221, Issue 4615, 1059-1061
Copyright © 1983 by American Association for the Advancement of Science

articles

Substance P and somatostatin regulate sympathetic noradrenergic function

JA Kessler, JE Adler, and IB Black

Peptidergic-noradrenergic interactions were examined in explants of rat sympathetic superior cervical ganglia and in cultures of dissociated cells. The putative peptide transmitters substance P and somatostatin each increased the activity of the catecholamine-synthesizing enzyme tyrosine hydroxylase after 1 week of exposure in culture. Maximal increases occurred at 10(-7) molar for each peptide, and either increasing or decreasing the concentration reduced the effects. Similar increases in tyrosine hydroxylase were produced by a metabolically stable agonist of substance P, while a substance P antagonist prevented the effects of the agonist. The data suggest that the increased tyrosine hydroxylase activity was mediated by peptide interaction with specific substance P receptors and that peptides may modulate sympathetic catecholaminergic function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
CSF Somatostatin and Abnormal Response to Dexamethasone Administration in Schizophrenic and Depressed Patients.
A. R. Doran, D. R. Rubinow, A. Roy, and D. Pickar (1986)
Arch Gen Psychiatry 43, 365-369
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