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Science 2 September 1983:
Vol. 221. no. 4614, pp. 951 - 953
DOI: 10.1126/science.6879192
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Articles

Science, Vol 221, Issue 4614, 951-953
Copyright © 1983 by American Association for the Advancement of Science

articles

Multiclonal origin of polyps in Gardner syndrome

SH Hsu, GD Luk, AJ Krush, SR Hamilton, and HH Hoover Jr

Electrophoretic analysis of glucose-6-phosphate dehydrogenase was performed on polyp tissue from three black female patients with Gardner syndrome and who are heterozygous for the A and B forms of this enzyme. Polyp tissues from the three patients displayed the AB phenotype. This finding suggests a multiclonal origin of polyps in Gardner syndrome. Studies of tumors originating from such polyps may provide information about the sequence of cellular events leading to malignant transformation.


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