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Science 26 August 1983:
Vol. 221. no. 4613, pp. 879 - 881
DOI: 10.1126/science.6879186
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Articles

Science, Vol 221, Issue 4613, 879-881
Copyright © 1983 by American Association for the Advancement of Science

articles

Circumventing the blood-brain barrier with autonomic ganglion transplants

JM Rosenstein and MW Brightman

Superior cervical ganglia, whose vessels are fenestrated and permeable to protein tracers such as horseradish peroxidase, were transplanted to undamaged surfaces in the fourth ventricle of rat pup brains. Horseradish peroxidase, infused systemically into the host, was exuded from the graft's vessels into the graft's extracellular stroma within 1 minute. At later times the glycoprotein reached the extracellular clefts of adjacent brain tissue, the vessels of which appeared to retain their impermeability. The blood-brain barrier to horseradish peroxide was thus bypassed where the extracellular compartments of graft and brain became confluent. The graft of autonomic ganglia can serve as a portal through which peptides, hormones, and immunoglobulins may likewise enter the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neocortical transplants in the mammalian brain lack a blood-brain barrier to macromolecules.
J. Rosenstein (1987)
Science 235, 772-774
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