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Science 26 August 1983:
Vol. 221. no. 4613, pp. 875 - 877
DOI: 10.1126/science.6603658
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Articles

Science, Vol 221, Issue 4613, 875-877
Copyright © 1983 by American Association for the Advancement of Science

articles

Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons

JB Aldenhoff, DL Gruol, J Rivier, W Vale, and GR Siggins

Corticotropin releasing factor in concentrations of 15 to 250 nanomoles per liter increased the spontaneous discharge frequency and decreased the size of hyperpolarizations after burst discharges in CA1 and CA3 pyramidal neurons of rat hippocampal slices. Concentrations greater than 250 nanomoles per liter also depolarized the cells. These excitatory actions of corticotropin releasing factor may involve a novel calcium-dependent process.


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Corticotropin-Releasing Factor Increases Dihydropyridine- and Neurotoxin-Resistant Calcium Currents in Neurons of the Central Amygdala.
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The coupling of neurotransmitter receptors to ion channels in the brain.
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