Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 August 1983:
Vol. 221. no. 4613, pp. 871 - 873
DOI: 10.1126/science.6879185
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4613, 871-873
Copyright © 1983 by American Association for the Advancement of Science

articles

Morphine tolerance in genetically selected rats induced by chronically elevated saccharin intake

I Lieblich, E Cohen, Ganchrow JR, EM Blass, and F Bergmann

Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharin solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharin intake may cause increased release and utilization of endogenous opiates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effectiveness of sucrose analgesia in newborns undergoing painful medical procedures.
A. Taddio BScPhm PhD, V. Shah MD MSc, R. Hancock MSc, R. W. Smith BASc MSc, D. Stephens MSc, E. Atenafu MSc, J. Beyene PhD, G. Koren MD, B. Stevens RN PhD, and J. Katz PhD (2008)
Can. Med. Assoc. J. 179, 37-43
   Abstract »    Full Text »    PDF »
Effect of Dextromethorphan, Diphenhydramine, and Placebo on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents.
J. Walburn (2004)
Pediatrics 114, 1370
   Full Text »    PDF »
ASSOCIATION BETWEEN PREFERENCE FOR SWEETS AND EXCESSIVE ALCOHOL INTAKE: A REVIEW OF ANIMAL AND HUMAN STUDIES.
A. B. Kampov-Polevoy, J. C. Garbutt, and D. S. Janowsky (1999)
Alcohol Alcohol. 34, 386-395
   Abstract »    Full Text »    PDF »
Milk-induced Hypoalgesia in Human Newborns.
E. M. Blass (1997)
Pediatrics 99, 825-829
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)