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Science 26 August 1983:
Vol. 221. no. 4613, pp. 853 - 855
DOI: 10.1126/science.6603657
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Articles

Science, Vol 221, Issue 4613, 853-855
Copyright © 1983 by American Association for the Advancement of Science

articles

Immune response to hepatitis B surface antigen: enhancement by prior injection of antibodies to the idiotype

RC Kennedy, K Adler-Storthz, RD Henkel, Y Sanchez, JL Melnick, and GR Dreesman

Anti-idiotype reagents that recognize a common idiotype associated with the combining site of antibodies to hepatitis B surface antigen (anti-HBs) were used to manipulate the immune response to hepatitis B surface antigen in BALB/c mice. The injection of antibodies to the idiotype before antigenic stimulation resulted in an increase in the number of cells secreting immunoglobulin M antibodies to hepatitis B surface antigen. Anti-HBs-secreting cells were also induced by administration of antibodies to the idiotype without subsequent antigen exposure. These findings indicate that the immune response to hepatitis B surface antigen in mice is regulated through an idiotype-anti-idiotype network.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees.
R. Kennedy, J. Eichberg, R. Lanford, and G. Dreesman (1986)
Science 232, 220-223
   Abstract »    PDF »
Antibody to hepatitis B virus induced by injecting antibodies to the idiotype.
R. Kennedy, J. Melnick, and G. Dreesman (1984)
Science 223, 930-931
   Abstract »    PDF »


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