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Science 19 August 1983:
Vol. 221. no. 4612, pp. 764 - 766
DOI: 10.1126/science.6348944
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Articles

Science, Vol 221, Issue 4612, 764-766
Copyright © 1983 by American Association for the Advancement of Science

articles

Malaria parasites adopt host cell superoxide dismutase

AS Fairfield, Meshnick SR, and JW Eaton

Aerobic organisms depend on superoxide dismutase to suppress the formation of dangerous species of activated oxygen. Intraerythrocytic stages of the malaria parasite exist within a highly aerobic environment and cause the generation of increased amounts of activated oxygen. Plasmodium berghei in mice was found to derive a substantial amount of superoxide dismutase activity from the host cell cytoplasm. Plasmodia isolated from mouse red cells contained mouse superoxide dismutase, whereas rat-derived parasites contained the rat enzyme. This is believed to be the first example of the acquisition of a host cell enzyme by an intracellular parasite.


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The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification.
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Immunoprecipitation of [3H]Dihydroartemisinin Translationally Controlled Tumor Protein (TCTP) Adducts from Plasmodium falciparum-Infected Erythrocytes by Using Anti-TCTP Antibodies.
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Mechanisms of Artemisinin Resistance in the Rodent Malaria Pathogen Plasmodium yoelii.
D. J. Walker, J. L. Pitsch, M. M. Peng, B. L. Robinson, W. Peters, J. Bhisutthibhan, and S. R. Meshnick (2000)
Antimicrob. Agents Chemother. 44, 344-347
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