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Science 19 August 1983:
Vol. 221. no. 4612, pp. 758 - 760
DOI: 10.1126/science.6192499
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Articles

Science, Vol 221, Issue 4612, 758-760
Copyright © 1983 by American Association for the Advancement of Science

articles

Expression of streptococcal M protein in Escherichia coli

Scott JR and VA Fischetti

The structural gene for group A streptococcal M protein, the fibrillar surface molecule enabling the organism to resist phagocytosis, has been cloned into Escherichia coli. The molecule produced by Escherichia coli is slightly larger than the M protein isolated by solubilization of the streptococcal cell wall, but is similar in size to that secreted by streptococcal protoplast and L forms. Immunologically, the molecule synthesized by Escherichia coli has the same type-specific determinants as the streptococcal M protein.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification and Characterization of the scl Gene Encoding a Group A Streptococcus Extracellular Protein Virulence Factor with Similarity to Human Collagen.
S. Lukomski, K. Nakashima, I. Abdi, V. J. Cipriano, R. M. Ireland, S. D. Reid, G. G. Adams, and J. M. Musser (2000)
Infect. Immun. 68, 6542-6553
   Abstract »    Full Text »    PDF »
Characterization of a Genetic Element Carrying the Macrolide Efflux Gene mef(A) in Streptococcus pneumoniae.
M. Santagati, F. Iannelli, M. R. Oggioni, S. Stefani, and G. Pozzi (2000)
Antimicrob. Agents Chemother. 44, 2585-2587
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Pathogenesis of Group A Streptococcal Infections.
M. W. Cunningham (2000)
Clin. Microbiol. Rev. 13, 470-511
   Abstract »    Full Text »    PDF »
A Response Regulator That Represses Transcription of Several Virulence Operons in the Group A Streptococcus.
M. J. Federle, K. S. McIver, and J. R. Scott (1999)
J. Bacteriol. 181, 3649-3657
   Abstract »    Full Text »
Small DNA deletions creating avirulence in Streptococcus pyogenes.
J. Spanier, S. Jones, and P Cleary (1984)
Science 225, 935-938
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