Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 August 1983:
Vol. 221. no. 4612, pp. 756 - 758
DOI: 10.1126/science.6308759
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4612, 756-758
Copyright © 1983 by American Association for the Advancement of Science

articles

Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid

CE Brinckerhoff, JW Coffey, and AC Sullivan

Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount of collagenase secreted in tissue culture by adherent cells isolated from the inflamed joints of adjuvant rats treated with 13-cis-retinoic acid also decreased as compared to the amount secreted by cells from vehicle-treated adjuvant rats. Collagenase is important in the joint destruction accompanying rheumatoid arthritis. The successful use of retinoids in the treatment of this proliferative but nonmalignant disorder demonstrates a new application of these compounds.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.
K. M. Elias, A. Laurence, T. S. Davidson, G. Stephens, Y. Kanno, E. M. Shevach, and J. J. O'Shea (2008)
Blood 111, 1013-1020
   Abstract »    Full Text »    PDF »
Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma..
J.-M. Yuan, Y.-T. Gao, C.-N. Ong, R. K. Ross, and M. C. Yu (2006)
J Natl Cancer Inst 98, 482-490
   Abstract »    Full Text »    PDF »
Effect of E6060 [4-{5-[7-Fluoro-4-(trifluoromethyl)benzo[b]furan-2-yl]-1H-2-pyrrolyl}benzoic Acid], a Novel Subtype-Selective Retinoid, on Lupus-Like Nephritis in Female (NZBxNZW)F1 Mice.
T. Yamauchi, A. Ishibashi, K. Shikata, N. Tokuhara, K.-i. Seino, S. Kobayashi, and M. Nagai (2005)
J. Pharmacol. Exp. Ther. 312, 938-944
   Abstract »    Full Text »    PDF »
Prevention of acute and chronic allograft rejection by a novel retinoic acid receptor-{alpha}-selective agonist.
K.-i. Seino, T. Yamauchi, K. Shikata, S. Kobayashi, M. Nagai, M. Taniguchi, and K. Fukao (2004)
Int. Immunol. 16, 665-673
   Abstract »    Full Text »    PDF »
Retinol measurements and retinoid receptor gene expression in patients with multiple sclerosis.
W Royal, S Gartner, and C D Gajewski (2002)
Multiple Sclerosis 8, 452-458
   Abstract »    PDF »
Retinoids and Carnosol Suppress Cyclooxygenase-2 Transcription by CREB-binding Protein/p300-dependent and -independent Mechanisms.
K. Subbaramaiah, P. A. Cole, and A. J. Dannenberg (2002)
Cancer Res. 62, 2522-2530
   Abstract »    Full Text »    PDF »
Destabilization of TNF-{alpha} mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease.
K. Motomura, M. Ohata, M. Satre, and H. Tsukamoto (2001)
Am J Physiol Endocrinol Metab 281, E420-E429
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinases: A Review.
H. Birkedal-Hansen, W.G.I. Moore, M.K. Bodden, L.J. Windsor, B. Birkedal-Hansen, A. DeCarlo, and J.A. Engler (1993)
Critical Reviews in Oral Biology & Medicine 4, 197-250
   Abstract »    Full Text »    PDF »
Retinoid Therapy for Rheumatoid Arthritis.
E. D. HARRIS JR. (1984)
Ann Intern Med 100, 146-147
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)