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Science 12 August 1983:
Vol. 221. no. 4611, pp. 677 - 679
DOI: 10.1126/science.6867739

Articles

Science, Vol 221, Issue 4611, 677-679
Copyright © 1983 by American Association for the Advancement of Science


articles

Alcohol self-administration disrupts reproductive function in female macaque monkeys

NK Mello, MP Bree, JH Mendelson, J Ellingboe, NW King, and P Sehgal

Female macaque monkeys self-administered high doses of alcohol (2.9 to 4.4 grams per kilogram per day) for 3 to 6 1/2 months. Amenorrhea, atrophy of the uterus, decreased ovarian mass, and significant depression of luteinizing hormone levels were associated with chronic alcohol intoxication. Reproductive system failure in female primates following self-induced dependence on alcohol parallels the results of clinical studies of alcoholic women.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy.
T. K. Jensen, N. H. I Hjollund, T. B. Henriksen, T. Scheike, H. Kolstad, A. Giwercman, E. Ernst, J. P. Bonde, N. E Skakkebæk, and J. Olsen (1998)
BMJ 317, 505-510
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The Effects of Chronic Cocaine Self-Administration on the Menstrual Cycle in Rhesus Monkeys.
N. K. Mello, J. H. Mendelson, M. Kelly, N. Diaz-Migoyo, and J. W. Sholar (1997)
J. Pharmacol. Exp. Ther. 281, 70-83
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Anticardiolipin antibodies and acute alcoholic intoxication.
C. Biron, N. Lalloyer, J.L. Tonnelot, D. Larget, J.C. Gris, and J.F. Schved (1995)
Lupus 4, 486-490
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