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Science 12 August 1983:
Vol. 221. no. 4611, pp. 614 - 620
DOI: 10.1126/science.6867732
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Articles

Science, Vol 221, Issue 4611, 614-620
Copyright © 1983 by American Association for the Advancement of Science

articles

Choline and cholinergic neurons

JK Blusztajn and RJ Wurtman

Mammalian neurons can synthesize choline by methylating phosphatidylethanolamine and hydrolyzing the resulting phosphatidylcholine. This process is stimulated by catecholamines. The phosphatidylethanolamine is synthesized in part from phosphatidylserine; hence the amino acids methionine (acting after conversion to S-adenosylmethionine) and serine can be the ultimate precursors of choline. Brain choline concentrations are generally higher than plasma concentrations, but depend on plasma concentrations because of the kinetic characteristics of the blood-brain-barrier transport system. When cholinergic neurons are activated, acetylcholine release can be enhanced by treatments that increase plasma choline (for example, consumption of certain foods).


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