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Science 5 August 1983:
Vol. 221. no. 4610, pp. 578 - 579
DOI: 10.1126/science.6306771
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Articles

Science, Vol 221, Issue 4610, 578-579
Copyright © 1983 by American Association for the Advancement of Science

articles

Epstein-Barr virus: inhibition of replication by three new drugs

JC Lin, MC Smith, YC Cheng, and JS Pagano

Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and is associated with three human malignancies. Acyclovir [9-(2-hydroxyethoxymethyl)guanine], the first clinically useful drug effective against replication of EBV, is without effect against latent or persistent EBV infection. Three nucleoside analogs, E-5-(2-bromovinyl)-2'-deoxyuridine, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine, and 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil are potent inhibitors of EBV replication in vitro. Moreover, in contrast to the reversibility of viral inhibition by Acyclovir, these three drugs have prolonged effects in suppressing viral replication even after the drugs are removed from persistently infected cell cultures.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Epstein-Barr Virus Infection in Ex Vivo Tonsil Epithelial Cell Cultures of Asymptomatic Carriers.
D. M. Pegtel, J. Middeldorp, and D. A. Thorley-Lawson (2004)
J. Virol. 78, 12613-12624
   Abstract »    Full Text »    PDF »
Inhibition of Epstein-Barr Virus Replication by a Benzimidazole L-Riboside: Novel Antiviral Mechanism of 5,6-Dichloro-2-(Isopropylamino)-1-beta -L-Ribofuranosyl-1H-Benzimidazole.
V. L. Zacny, E. Gershburg, M. G. Davis, K. K. Biron, and J. S. Pagano (1999)
J. Virol. 73, 7271-7277
   Abstract »    Full Text »    PDF »


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