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Science 5 August 1983:
Vol. 221. no. 4610, pp. 568 - 570
DOI: 10.1126/science.6603018
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Articles

Science, Vol 221, Issue 4610, 568-570
Copyright © 1983 by American Association for the Advancement of Science

articles

Coping and immunosuppression: inescapable but not escapable shock suppresses lymphocyte proliferation

ML Laudenslager, SM Ryan, RC Drugan, RL Hyson, and SF Maier

Rats were given series of escapable shocks, identical inescapable shocks, or no shock. The subjects were reexposed to a small amount of shock 24 hours later, after which an in vitro measure of the cellular immune response was examined. Lymphocyte proliferation in response to the mitogens phytohemagglutinin and concanavalin A was suppressed in the inescapable shock group but not in the escapable shock group. This suggests that the controllability of stressors is critical in modulating immune functioning.


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