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Science 29 July 1983:
Vol. 221. no. 4609, pp. 474 - 476
DOI: 10.1126/science.6683428
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Articles

Science, Vol 221, Issue 4609, 474-476
Copyright © 1983 by American Association for the Advancement of Science

articles

Light and propranolol suppress the nocturnal elevation of serotonin in the cerebrospinal fluid of rhesus monkeys

NA Garrick, L Tamarkin, PL Taylor, SP Markey, and DL Murphy

Markedly elevated nighttime concentrations of serotonin in rhesus monkey cerebrospinal fluid were reduced to daytime levels by exposing the monkeys to continuous light or to the beta-adrenergic antagonist propranolol. Nighttime elevations of melatonin in cerebrospinal fluid were also suppressed by propranolol and light. Serotonin released in large quantities at night appears to be regulated like melatonin, and may act as a cerebroventricular hormone to influence brain and pituitary function at night.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diurnal rhythms of N-acetylserotonin and serotonin in cerebrospinal fluid of monkeys.
P. Taylor, N. Garrick, L Tamarkin, D. Murphy, and S. Markey (1985)
Science 228, 900
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