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Science 15 July 1983:
Vol. 221. no. 4607, pp. 279 - 281
DOI: 10.1126/science.6857284
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Articles

Science, Vol 221, Issue 4607, 279-281
Copyright © 1983 by American Association for the Advancement of Science

articles

Cooperative immunoassays: ultrasensitive assays with mixed monoclonal antibodies

PH Ehrlich and WR Moyle

Mixtures of certain monoclonal antibodies appear to bind human chorionic gonadotropin in a "cooperative" fashion because they form circular complexes with the hormone. Experiments illustrate how this property might be exploited to develop very sensitive immunoassays for human chorionic gonadotropin or any other antigen. Since the assays are not based on competitive inhibition between radiolabeled and unlabeled antigen, they are much more sensitive than a traditional radioimmunoassay in which either one of the same antibodies is used alone.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)