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Science 15 July 1983:
Vol. 221. no. 4607, pp. 227 - 236
DOI: 10.1126/science.6336310
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Articles

Science, Vol 221, Issue 4607, 227-236
Copyright © 1983 by American Association for the Advancement of Science

articles

The chromosomal basis of human neoplasia

JJ Yunis

High-resolution banding techniques for the study of human chromosomes have revealed that the malignant cells of most tumors analyzed have characteristic chromosomal defects. Translocations of the same chromosome segments with precise breakpoints occur in many leukemias and lymphomas, and a specific chromosome band is deleted in several carcinomas. Trisomy, or the occurrence of a particular chromosome in triplicate, is the only abnormality observed in a few neoplasias. It is proposed that chromosomal rearrangements play a central role in human neoplasia and may exert their effects through related genomic mechanisms. Thus, a translocation could serve to place an oncogene next to an activating DNA sequence, a deletion to eliminate an oncogene repressor, and trisomy to carry extra gene dosage.


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