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Science 8 July 1983:
Vol. 221. no. 4606, pp. 192 - 193
DOI: 10.1126/science.6602381
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Articles

Science, Vol 221, Issue 4606, 192-193
Copyright © 1983 by American Association for the Advancement of Science

articles

Antipyretic potency of centrally administered alpha-melanocyte stimulating hormone

MT Murphy, DB Richards, and JM Lipton

Centrally administered alpha-melanocyte stimulating hormone is much more potent in reducing fever than the widely used antipyretic acetaminophen. This finding supports the hypothesis that the endogenous neuropeptide has a role in the limitation of fever and suggests that it may be clinically useful as an antipyretic.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{alpha}-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effects in Vitro and in Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases.
T. Brzoska, T. A. Luger, C. Maaser, C. Abels, and M. Bohm (2008)
Endocr. Rev. 29, 581-602
   Abstract »    Full Text »    PDF »
Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation.
A. Catania, S. Gatti, G. Colombo, and J. M. Lipton (2004)
Pharmacol. Rev. 56, 1-29
   Abstract »    Full Text »    PDF »
A Novel Antipyretic Action of 15-Deoxy-{Delta}12,14-Prostaglandin J2 in the Rat Brain.
A. Mouihate, L. Boisse, and Q. J. Pittman (2004)
J. Neurosci. 24, 1312-1318
   Abstract »    Full Text »    PDF »
Plasma concentrations of {alpha}-melanocyte-stimulating hormone are elevated in patients on chronic haemodialysis.
L. Airaghi, L. Garofalo, M. G. Cutuli, R. Delgado, A. Carlin, M. T. Demitri, S. Badalamenti, G. Graziani, J. M. Lipton, and A. Catania (2000)
Nephrol. Dial. Transplant. 15, 1212-1216
   Abstract »    Full Text »    PDF »
Role of cytochrome P-450 in endogenous antipyresis.
W. Kozak, M. J. Kluger, A. Kozak, M. Wachulec, and K. Dokladny (2000)
Am J Physiol Regulatory Integrative Comp Physiol 279, R455-R460
   Abstract »    Full Text »    PDF »
Concepts of Fever.
P. A. Mackowiak (1998)
Arch Intern Med 158, 1870-1881
   Abstract »    Full Text »
The cloning of a family of genes that encode the melanocortin receptors.
K. Mountjoy, L. Robbins, M. Mortrud, and R. Cone (1992)
Science 257, 1248-1251
   Abstract »    PDF »
Brain peptides: what, where, and why?.
D. Krieger (1983)
Science 222, 975-985
   Abstract »    PDF »


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