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Science 8 July 1983:
Vol. 221. no. 4606, pp. 163 - 165
DOI: 10.1126/science.6857275
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Articles

Science, Vol 221, Issue 4606, 163-165
Copyright © 1983 by American Association for the Advancement of Science

articles

Salicylate and mitochondrial injury in Reye's syndrome

K You

Electron microscopic and spectrophotometric studies showed that salicylate causes gross swelling of mitochondria in isotonic salt solutions. In overall morphology the salicylate-treated mitochondria resembled those from patients with Reye's syndrome. Salicylate analogs such as m-hydroxybenzoate, p-hydroxybenzoate, and benzoate did not exert this effect. The mitochondria deformed by salicylate tended to return to their original condensed form on removal of the drug.


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