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Science 1 July 1983:
Vol. 221. no. 4605, pp. 83 - 85
DOI: 10.1126/science.6407113
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Articles

Science, Vol 221, Issue 4605, 83-85
Copyright © 1983 by American Association for the Advancement of Science

articles

A gene controlling condensation of heterochromatin in Drosophila melanogaster

M Gatti, DA Smith, and BS Baker

A temperature-sensitive lethal mutant of Drosophila melanogaster was used to identify an essential cell cycle function that is necessary for the mitotic condensation of heterochromatic but not of euchromatic portions of the genome. This mutant is an allele at a locus (mus-101) identified earlier by the use of mutagen-sensitive mutants. The data suggest that the mutagen-sensitive and repair-defective phenotypes of viable mus-101 mutants result from a disruption in chromosome organization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Systematic, RNA-Interference-Mediated Identification of mus-101 Modifier Genes in Caenorhabditis elegans.
A. H. Holway, C. Hung, and W. M. Michael (2005)
Genetics 169, 1451-1460
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A Large-Scale Screen for Mutagen-Sensitive Loci in Drosophila.
A. Laurencon, C. M. Orme, H. K. Peters, C. L. Boulton, E. K. Vladar, S. A. Langley, E. P. Bakis, D. T. Harris, N. J. Harris, S. M. Wayson, et al. (2004)
Genetics 167, 217-231
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Overexpression of the SuUR gene induces reversible modifications at pericentric, telomeric and intercalary heterochromatin of Drosophila melanogaster polytene chromosomes.
I. F. Zhimulev, E. S. Belyaeva, V. F. Semeshin, V. V. Shloma, I. V. Makunin, and E. I. Volkova (2003)
J. Cell Sci. 116, 169-176
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The Drosophila mus101 Gene, Which Links DNA Repair, Replication and Condensation of Heterochromatin in Mitosis, Encodes a Protein With Seven BRCA1 C-Terminus Domains.
R. R. Yamamoto, J. M. Axton, Y. Yamamoto, R. D. C. Saunders, D. M. Glover, and D. S. Henderson (2000)
Genetics 156, 711-721
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The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability..
C B Brachmann, J M Sherman, S E Devine, E E Cameron, L Pillus, and J D Boeke (1995)
Genes & Dev. 9, 2888-2902
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polo encodes a protein kinase homolog required for mitosis in Drosophila..
S Llamazares, A Moreira, A Tavares, C Girdham, B A Spruce, C Gonzalez, R E Karess, D M Glover, and C E Sunkel (1991)
Genes & Dev. 5, 2153-2165
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Genes controlling essential cell-cycle functions in Drosophila melanogaster..
M Gatti and B S Baker (1989)
Genes & Dev. 3, 438-453
   Abstract »    PDF »
BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response.
M. Makiniemi, T. Hillukkala, J. Tuusa, K. Reini, M. Vaara, D. Huang, H. Pospiech, I. Majuri, T. Westerling, T. P. Makela, et al. (2001)
J. Biol. Chem. 276, 30399-30406
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