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Science 1 July 1983:
Vol. 221. no. 4605, pp. 77 - 79
DOI: 10.1126/science.6304879
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Articles

Science, Vol 221, Issue 4605, 77-79
Copyright © 1983 by American Association for the Advancement of Science

articles

Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation

TA Dix and LJ Marnett

Lipid peroxidation triggered by ascorbate or reduced nicotinamide adenine dinucleotide in rat liver microsomes can initiate the epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene. The stereochemistry of epoxidation is indicative of a peroxide-dependent free radical process. Since the epoxides formed may be the most carcinogenic derivatives of benzo[a]pyrene yet identified, lipid peroxidation can effect the metabolic activation of proximate carcinogens to ultimate carcinogens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fatty Acid Hydroperoxides Support Cytochrome P450 2S1-Mediated Bioactivation of Benzo[a]pyrene-7,8-dihydrodiol.
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Mol. Pharmacol. 76, 1044-1052
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The Growing Burden of Chronic Obstructive Pulmonary Disease and Lung Cancer in Women: Examining Sex Differences in Cigarette Smoke Metabolism.
S. Ben-Zaken Cohen, P. D. Pare, S. F. P. Man, and D. D. Sin (2007)
Am. J. Respir. Crit. Care Med. 176, 113-120
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Myeloperoxidase - 463A variant reduces benzo[a]pyrene diol epoxide DNA adducts in skin of coal tar treated patients.
M. Rojas, R. Godschalk, K. Alexandrov, I. Cascorbi, E. Kriek, J. Ostertag, F.-J. Van Schooten, and H. Bartsch (2001)
Carcinogenesis 22, 1015-1018
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Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.
A. Chaudhary, M Nokubo, G. Reddy, S. Yeola, J. Morrow, I. Blair, and L. Marnett (1994)
Science 265, 1580-1582
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The Role of Metabolism in Chemical-Induced Pulmonary Toxicity*1.
B. R. Smith and W. R. Brian (1991)
Toxicol Pathol 19, 470-481
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