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Science 1 July 1983:
Vol. 221. no. 4605, pp. 75 - 77
DOI: 10.1126/science.6857269
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Articles

Science, Vol 221, Issue 4605, 75-77
Copyright © 1983 by American Association for the Advancement of Science

articles

Inhibition of tumor promotion by a biomimetic superoxide dismutase

TW Kensler, DM Bush, and WJ Kozumbo

A low molecular weight, lipophilic, copper coordination complex with superoxide dismutase-mimetic activity inhibited biochemical and biological actions of a tumor promoter in mouse epidermis. Such inhibitory effects implicate reactive oxygen species in the tumor promotion process.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Magnetic Resonance Imaging Contrast Agent Mangafodipir Exerts Antitumor Activity via a Previously Described Superoxide Dismutase Mimetic Activity.
J. O. G. Karlsson, H. Brurok, R. Towart, P. Jynge, and F. Batteux (2006)
Cancer Res. 66, 598
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Estrogen-Like Activity of Metals in Mcf-7 Breast Cancer Cells.
M. B. Martin, R. Reiter, T. Pham, Y. R. Avellanet, J. Camara, M. Lahm, E. Pentecost, K. Pratap, B. A. Gilmore, S. Divekar, et al. (2003)
Endocrinology 144, 2425-2436
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Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis.
L. M. Landino, B. C. Crews, M. D. Timmons, J. D. Morrow, and L. J. Marnett (1996)
PNAS 93, 15069-15074
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Abnormalities in Serum Lipids and Leukocyte Superoxide Dismutase and Associated Cataract Formation in Patients With Atopic Dermatitis.
Y. Niwa and O. Iizawa (1994)
Arch Dermatol 130, 1387-1392
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Inhibition of Tumor Development by Dehydroepiandrosterone and Related Steroids.
A. G. Schwartz, L. Pashko, and J. M. Whitcomb (1986)
Toxicol Pathol 14, 357-362
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Studies on the Mechanisms by Which Tumor Promoters Stimulate the Growth of Primary Neonatal Rat Hepatocytes.
F. Romano, P. G. Andreis, C. Marchesini, L. Paccagnella, and U. Armato (1986)
Toxicol Pathol 14, 375-385
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Prooxidant states and tumor promotion.
P. Cerutti (1985)
Science 227, 375-381
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Malignant Neoplasia in Patients With Abdominal Aortic Aneurysms.
M. D. Tilson, E. L. Fieg, and M. Harvey (1984)
Arch Surg 119, 792-794
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