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Science 1 July 1983:
Vol. 221. no. 4605, pp. 63 - 65
DOI: 10.1126/science.6407112
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Articles

Science, Vol 221, Issue 4605, 63-65
Copyright © 1983 by American Association for the Advancement of Science

articles

Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A

GH Reem, LA Cook, and J Vilcek

Cyclosporin A depresses the synthesis of gamma interferon by human thymocytes and T lymphocytes in vitro. This observation is of potential clinical significance because the long-term treatment of transplant patients with cyclosporin A, a widely used immunosuppressive agent, can give rise to B-cell lymphoma resulting from Epstein-Barr virus activation.


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Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.
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Cyclosporine Inhibits Basic Fibroblast Growth Factor-Driven Proliferation of Human Endothelial Cells and Keratinocytes.
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Cyclosporin A in Severe, Treatment-Refractory Rheumatoid Arthritis: A Randomized Study.
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A Double-blind Study of the Effectiveness of Cyclosporine in Amyotrophic Lateral Sclerosis.
S. H. Appel, S. S. Stewart, V. Appel, Y. Harati, W. Mietlowski, W. Weiss, and G. W. Belendiuk (1988)
Arch Neurol 45, 381-386
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Dermatologic Applications of Cyclosporine.
t. A. Biren and R. J. Barr (1986)
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Cyclosporine: A New Immunosuppressive Agent for Organ Transplantation.
D. J. COHEN, R. LOERTSCHER, M. F. RUBIN, N. L. TILNEY, C. B. CARPENTER, and T. B. STROM (1984)
Ann Intern Med 101, 667-682
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Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes.
G. Reem and N. Yeh (1984)
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