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Science 1 July 1983:
Vol. 221. no. 4605, pp. 51 - 53
DOI: 10.1126/science.6857261
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Articles

Science, Vol 221, Issue 4605, 51-53
Copyright © 1983 by American Association for the Advancement of Science

articles

Inhibition by alcohols of the localization of radioactive nitrosonornicotine in sites of tumor formation

WJ Waddell and C Marlowe

Oral administration of ethanol, n-butanol, or t-butanol to mice 20 minutes before injection of carbon-14-labeled nitrosonornicotine inhibited the localization of radioactivity in bronchial and salivary duct epithelium and in the liver. Localization of radioactivity in the nasal epithelium and esophagus was not significantly reduced. These alcohols therefore may selectively inhibit tumor formation in three of the five sites where this carcinogen typically acts.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Waddell reply to letter of Andersen and Renwick.
W J Waddell (2005)
Human and Experimental Toxicology 24, 605-606
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