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Science 24 June 1983:
Vol. 220. no. 4604, pp. 1407 - 1408
DOI: 10.1126/science.6857259
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Articles

Science, Vol 220, Issue 4604, 1407-1408
Copyright © 1983 by American Association for the Advancement of Science

articles

Accumulation of D-aspartic acid with age in the human brain

EH Man, ME Sandhouse, J Burg, and GH Fisher

An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Collagen Turnover in Normal and Degenerate Human Intervertebral Discs as Determined by the Racemization of Aspartic Acid.
S.-S. Sivan, E. Wachtel, E. Tsitron, N. Sakkee, F. van der Ham, J. DeGroot, S. Roberts, and A. Maroudas (2008)
J. Biol. Chem. 283, 8796-8801
   Abstract »    Full Text »    PDF »
Aggrecan Turnover in Human Intervertebral Disc as Determined by the Racemization of Aspartic Acid.
S. S. Sivan, E. Tsitron, E. Wachtel, P. J. Roughley, N. Sakkee, F. van der Ham, J. DeGroot, S. Roberts, and A. Maroudas (2006)
J. Biol. Chem. 281, 13009-13014
   Abstract »    Full Text »    PDF »
Paenidase, a Novel D-Aspartyl Endopeptidase from Paenibacillus sp. B38: Purification and Substrate Specificity.
S. Takahashi, H. Ogasawara, K. Hiwatashi, K. Hori, K. Hata, T. Tachibana, Y. Itoh, and T. Sugiyama (2006)
J. Biochem. 139, 197-202
   Abstract »    Full Text »    PDF »
Effect of Collagen Turnover on the Accumulation of Advanced Glycation End Products.
N. Verzijl, J. DeGroot, S. R. Thorpe, R. A. Bank, J. N. Shaw, T. J. Lyons, J. W. J. Bijlsma, F. P. J. G. Lafeber, J. W. Baynes, and J. M. TeKoppele (2000)
J. Biol. Chem. 275, 39027-39031
   Abstract »    Full Text »    PDF »


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