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Science 24 June 1983:
Vol. 220. no. 4604, pp. 1383 - 1385
DOI: 10.1126/science.6407109
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Articles

Science, Vol 220, Issue 4604, 1383-1385
Copyright © 1983 by American Association for the Advancement of Science

articles

Atypical pulmonary thrombosis caused by a toxic cyanobacterial peptide

DN Slatkin, RD Stoner, WH Adams, JH Kycia, and HW Siegelman

Parenteral injection into mice of a toxic pentapeptide isolated from the cyanobacterium Microcystis aeruginosa induced thrombocytopenia, pulmonary thrombi, and hepatic congestion. The lethality of the toxin was unaffected by several anticoagulants. The acute liver damage that follows injection of the toxin has been attributed to direct action on liver cells but may be due to hypoxemia, heart failure, and shock.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)