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Science 17 June 1983:
Vol. 220. no. 4603, pp. 1309 - 1311
DOI: 10.1126/science.6857253
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Articles

Science, Vol 220, Issue 4603, 1309-1311
Copyright © 1983 by American Association for the Advancement of Science

articles

Hypothalamic gamma-aminobutyric acid neurons project to the neocortex

Vincent SR, T Hokfelt, LR Skirboll, and JY Wu

Three groups of gamma-aminobutyric acid--containing neurons were found in the mammillary region of the posterior hypothalamus. The groups correspond to the tuberal, caudal, and postmammillary caudal magnocellular nuclei. Many cells in these nuclei were retrogradely labeled with fast blue after the injection of this fluorescent dye into the neocortex. Immunohistochemical experiments showed that these same neurons also contained the gamma-aminobutyric acid-synthesizing enzyme glutamate decarboxylase. These results provide morphological evidence for a gamma-aminobutyric acid pathway arising in magnocellular neurons of the posterior hypothalamus and innervating the neocortex.


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