Science, Vol 220, Issue 4602, 1173-1175
Copyright © 1983 by American Association for the Advancement of Science
Hemoglobin aggregation in single red blood cells of sickle cell anemia
I Nishio,
T Tanaka,
ST Sun,
Y Imanishi,
and
ST Ohnishi
A laser light scattering technique was used to observe the extent of hemoglobin aggregation in solitary red blood cells of sickle cell anemia. Hemoglobin aggregation was confirmed in deoxygenated cells. The light scattering technique can also be applied to cytoplasmic studies of any biological cell.